A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.
TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V79423 | FITC-labeled ODN 1668 sodium | FITC-labeled ODN 1668 (sodium) is a class B CpG ODN and a TLR9 agonist. | |
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V79424 | FITC-labeled ODN 1826 sodium | FITC-labeled ODN 1826 (sodium) is a class B CpG ODN and a TLR9 agonist. | |
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V79425 | FITC-labeled ODN 2088 sodium | FITC-labeled ODN 2088 (sodium) is a TLR3, TLR7 and TLR9 inhibitor. | |
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V77014 | FITC-labeled ODN 2216 sodium | FITC-labeled ODN 2216 (sodium) is a TLR9 agonist. | |
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V79426 | FITC-labeled ODN 2395 sodium | FITC-labeled ODN 2395 (sodium) is a class C CpG ODN and a TLR9 agonist. | |
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V79427 | FITC-labeled ODN TTAGGG sodium | FITC-labeled ODN TTAGGG (sodium) is an inhibitor oligonucleotide that is an antagonist of TLR9, AIM2 and cGAS. | |
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V51032 | FSL-1 | 322455-70-9 | FSL-1 is a bacterially derived Toll-like receptor 2/6 (TLR2/6) agonist that enhances resistance to HSV-2 infection. |
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V79522 | FSL-1 TFA | FSL-1 TFA is a bacterially derived Toll-like receptor 2/6 (TLR2/6) agonist that enhances resistance to HSV-2 infection. | |
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V21515 | Gardiquimod | 1020412-43-4 | Gardiquimod, an imidazoquinoline compound, is a novel, potent and specific agonist of TLR7 (toll-like receptor 7)with antitumor and immunomodulatory effects. |
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V3332 | Gardiquimod trifluoroacetate | 1159840-61-5 | Gardiquimod diTFA, an imidazoline analog and TLR7/8 agonist. |
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V76947 | Guretolimod hydrochloride (DSP-0509 hydrochloride) | Guretolimod HCl is a Toll-like receptor 7 (TLR7) agonist. | |
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V74362 | HE-S2 | 2939851-67-7 | HE-S2 is an antibody-drug-conjugate/ADC that triggers potent anti-tumor immune responses. |
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V3267 | Imiquimod | 99011-02-6 | Imiquimod (S-26308; R-837; TMX-101; Aldara; Zyclara) is an immune response modifier that acts as an agonist of the TLR7 (toll-like receptor 7). |
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V51874 | Lefitolimod (MGN 1703) | 1548439-51-5 | Lefitolimod (MGN 1703) is a DNA-based TLR9 agonist and immune surveillance reactivator. |
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V80551 | Lefitolimod sodium (MGN 1703 sodium) | Lefitolimod (MGN 1703) sodium is a DNA-based TLR9 agonist and immune surveillance reactivator. | |
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V60063 | Lipopolysaccharides (LPS) | Lipopolysaccharides (LPS), consisting of an antigen O-specific chain, a core oligosaccharide and lipid A, is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. | |
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V24425 | Loxoribine | 121288-39-9 | Loxoribine (7-Allyl-8-oxoguanosine; RWJ-21757) is a novel and potent immunostimulant agent acting asan orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. |
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V3364 | M5049 | 2101938-42-3 | Enpatoran (M-5049) is a novel and selective inhibitor of Toll-Like Receptor 7/8 with IC50 of 11.1 and 24 nM, respectively. |
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V74344 | M62812 | 613263-00-6 | M62812 is a toll-like receptor 4 (TLR4) signaling inhibitor. |
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V74357 | M62812 free base | 613262-61-6 | M62812 (free base) is a toll-like receptor 4 (TLR4) signaling inhibitor. |
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