A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.
TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V51760 | TLR7 agonist 8 | 2380231-81-0 | TLR7 agonist 8 (compound IIb-34) is a potent TLR7 agonist/activator with EC50 of about 4 nM. |
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V51757 | TLR7 agonist 9 | 2389988-38-7 | TLR7 agonist 9 (compound 10) is a TLR7 agonist that may be utilized in cancer and infection research. |
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V40861 | TLR7/8 agonist 1 | 1258457-59-8 | TLR7/8 agonist 1is an agonist of TLR7/8 that can be used as an adjuvant for skin treatment of virus-associated warts and basal cell carcinoma. |
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V51767 | TLR7/8 agonist 4 | 2388520-33-8 | TLR7/8 agonist 4 (compound 41) is a potent TLR7/8 agonist. |
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V51768 | TLR7/8 agonist 7 | 2567953-47-1 | TLR7/8 agonist 7 (compound 10) is a TLR7/8 agonist. |
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V51774 | TLR7/8 agonist 8 | 2649170-16-9 | TLR7/8 Agonist 8 (Compound 24m) is a potent Toll-like receptor 7/8 (TLR7/8) dual agonist/activator with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. |
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V51770 | TLR7/8 agonist 9 | 2649170-17-0 | TLR7/8 agonist 9 (Compound 25a) is a TLR7/8 agonist/activator with EC50 of 40 nM and 23 nM for hTLR7/8. |
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V16508 | TLR7/8 agonist-5d | 1620278-72-9 | TLR7/8 agonist 1 diHCl is a dual agonist of the toll-like receptor TLR7/TLR8. |
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V51772 | TLR7/8 Antagonist 1 | 2901020-63-9 | TLR7/8 Antagonist 1 (Compound 16c) is a potent antagonist of TLR7/8 with IC50s of 3.91 and 2.19 μM respectively. |
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V51769 | TLR7/8 antagonist 2 | 2769085-03-0 | TLR7/8 Antagonist 2 (Compound 15) is a potent, interface-active TLR7/8 agonist/activator with IC50s of 4.9 and 0.6 nM, respectively. |
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V51771 | TLR7/8/9 antagonist 2 | 2920729-91-3 | TLR7/8/9 Antagonist 2 is a TLR7/8/9 antagonist (inhibitor) with cutoff activity. |
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V51773 | TLR7/8/9-IN-1 | 2180127-82-4 | TLR7/8/9-IN-1 is an orally bioavailable small molecule antagonist of Toll-like receptor 7/8/9 (TLR7/8/9) (IC50 = 43 nM). |
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V74361 | TLR7agonist 15 | 2832199-53-6 | TLR7 agonist 15 (compound 16b) is a potent TLR7 agonist/activator with EC50 of 59 nM. |
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V51786 | TLR8 agonist 2 | 2412937-64-3 | TLR8 Agonist 2 is a potent and specific TLR8 agonist/activator with EC50 of 3nM for human TLR8. |
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V51785 | TLR8 agonist 2 hydrochloride | 2412937-65-4 | TLR8 Agonist 2 HCl is a potent and specific TLR8 agonist/activator with EC50 of 3 nM for human TLR8. |
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V74346 | TLR8 agonist 5 | 2413016-41-6 | TLR8 agonist 5 is a potent TLR8 agonist/activator with EC50 of 20 nM for HEK-Blue hTLR8. |
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V74371 | TLR8 agonist 6 | 2616605-55-9 | TLR8 agonist 6 (Compound A) is a TLR8 agonist/activator with EC50 of 0.052 μM. |
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V51782 | TMX-201 | 1149339-78-5 | TMX-201 is a TLR7 ligand-phospholipid co-enhancer. |
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V74349 | Tomarilimab (OPN-305) | 1449294-76-1 | Tomarlimab (OPN-305) is a humanized anti-TLR2 (anti-TLR2) IgG4 monoclonal antibody (mAb). |
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V81611 | Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH | Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH is a linker containing the TLR4 inhibitor TLR4-IN-C34. |
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