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| 25mg |
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Description: Camalexin is a naturally occuring indole-based phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production. Camalexin has been used in quantification and tolerance assays in Arabidopsis thaliana leaves.
| ln Vitro |
Human breast cancer cell lines have antiproliferative activity in response to camalexin [2]. In oomycetes, the first steps toward the synthesis of Camalexin and the production of reactive oxygen species (ROS) are Phytophthora and Pythium Nep1-like proteins (necrosis and ethylene-inducing peptide 1-like proteins). ROS seem to have a ubiquitous role in the synthesis of camalexin. Camalexin synthesis and chemical stimulation of ROS (e.g., by applying acifluorfen) happen at the same time. An esa1 mutant with delayed Camalexin induction was found in a screen for enhanced susceptibility to Alternaria brassicae. The amounts of produced Camalexin are decreased, especially in reaction to ROS inducers. The fact that esa1 mutants are unable to produce Camalexin in response to Leptosphaeria maculans confirms the crucial role that ESA1 plays. Ups1, a different mutant that dramatically lowers Camalexin accumulation, was identified due to decreased tryptophan biosynthesis enzyme expression [2].
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| References | |
| Additional Infomation |
Camalexin is an indole phytoalexin that is indole substituted at position 3 by a 1,3-thiazol-2-yl group. It has a role as a metabolite. It is an indole phytoalexin and a member of 1,3-thiazoles.
Camalexin has been reported in Arabidopsis, Arabidopsis thaliana, and Camelina sativa with data available. |
| Molecular Formula |
C11H8N2S
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|---|---|
| Molecular Weight |
200.25962
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| Exact Mass |
200.041
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| CAS # |
135531-86-1
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| PubChem CID |
636970
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| Appearance |
White to yellow solid powder
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| Melting Point |
134 - 137 °C
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| LogP |
3.291
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
14
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| Complexity |
210
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
IYODIJVWGPRBGQ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C11H8N2S/c1-2-4-10-8(3-1)9(7-13-10)11-12-5-6-14-11/h1-7,13H
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| Chemical Name |
2-(1H-indol-3-yl)-1,3-thiazole
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~624.19 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (10.39 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (10.39 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (10.39 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.9935 mL | 24.9675 mL | 49.9351 mL | |
| 5 mM | 0.9987 mL | 4.9935 mL | 9.9870 mL | |
| 10 mM | 0.4994 mL | 2.4968 mL | 4.9935 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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