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    QNZ (EVP4593; CAY10470)
    QNZ (EVP4593; CAY10470)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0038
    CAS #: 545380-34-5Purity ≥98%

    Description: QNZ (also known as EVP-4593 or CAY-10470), a quinazoline derivative, is a novel and potent NF-κB inhibitor, which  shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in human Jurkat T cells, respectively. It was screened out from a luciferase reporter gene-based assay using human Jurkat T cells. EVP4593 reduced the number of lysosomes/autophagosomes and SOC currents in HD GMSLNs and exerted neuroprotective effects during cell aging. EVP4593 may be a promising anti-HD drug.

    ReferencesBioorg Med Chem. 2003 Feb 6;11(3):383-91; Chem Biol. 2011 Jun 24;18(6):777-93.

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    Molecular Weight (MW)356.42
    FormulaC22H20N4O
    CAS No.545380-34-5
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 5 mg/mL warming (14.0 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol: <1 mg/mL (slightly soluble or insoluble)
    Solubility (In vivo)0.5% hydroxyethyl cellulose: 30 mg/mL 
    Synonyms/Chemical NameCAY10470; CAY-10470; CAY 10470; EVP4593; EVP 4593; EVP-4593; 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine


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    In VitroEVP4593 inhibits TNF-a production from murine splenocytes stimulated with LPS with IC50 of 7 nM. EVP4593 (300 nM) entails a significant decrease of amplitude of store-operated currents (approximately by 60%), induced by application of 1 μM thapsigargin in Htt138Q cells, thus prevents abnormal store-operated calcium entry.
    In VivoEVP4593 (1 mg/kg, i.p.) dose-dependently inhibits carrageenin-induced paw edema in rats.
    Animal model male SD rats with carrageenin induced paw edema
    Formulation & Dosage 0.5% hydroxypropyl cellulose; 1 mg/kg; i.p injection
    References[1] Tobe M, et al. Bioorg Med Chem, 2003, 11(3), 383-391.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    QNZ (EVP4593)
    Identification of EVP4593 in climbing assay screen with HD transgenic flies. Chem Biol. 2011 Jun 24;18(6):777-93
     
    QNZ (EVP4593)
    SOC pathway in WT and YAC128 MSNs - Ca2+ imaging assay. Chem Biol. 2011 Jun 24;18(6):777-93
     
    QNZ (EVP4593)
    Compounds from EVP4593 series or knockdown of TRPC1 protect YAC128 MSNs from glutamate-induced apoptosis. Chem Biol. 2011 Jun 24;18(6):777-93


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