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    Pomalidomide (CC4047 or actimid)
    Pomalidomide (CC4047 or actimid)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0035
    CAS #: 19171-19-8 Purity ≥98%

    Description: Pomalidomide (formerly also known as CC-4047 or actimid), an analog of thalidomide, is a potent and orally bioavailable immunomodulatory molecule with antineoplastic activity.  It is commonly used as the ligand of E3 ligase in PROTACs (proteolysis targeting chimeras), a protein degradation technology. Pomalidomide was approved in 2013 by the US FDA for treatment for relapsed and refractory multiple myeloma, in particular, relapsed and refractory multiple myeloma (MM).  It is marketed as Pomalyst in the US and Imnovid in the European Union and Russia. 

    References: Bioorg Med Chem Lett. 1999 Jun 7;9(11):1625-30; Cancer Immunol Immunother. 2009 Jul;58(7):1033-45.

    Related CAS: 841-67-8 [(S)-Thalidomide]; 50-35-1 (racemic); 2098488-36-7 (Azido-Thalidomide) 

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    Molecular Weight (MW)273.24
    FormulaC13H11N3O4
    CAS No.19171-19-8
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 55 mg/mL (201.28 mM) )
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol: <1 mg/mL
    Solubility (In vivo) 1% DMSO+30% polyethylene glycol+1% Tween 80: 15 mg/mL
    Chemical Name/Synonyms4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; CC4047; CC 4047; CC-4047; Brand name: Pomalyst.


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    In VitroPomalidomide at 1 μM increased HbF production in human erythroid cells. After 6 days, Pomalidomide at 1 μM induced γ-globin mRNA levels upregulation 2-fold while decreased β-globin levels 2-fold.
    In VivoPomalidomide enhances the antitumor effect of rituximab against B-cell lymphomas in severe combined immunodeficient mice.
    Animal modelDisseminated lymphoma-bearing SCID mice
    Formulation & DosageDissolved in DMSO to make a 10 mg/mL stock solution and diluted to a final concentration of 1 mg/mL in sterile 0.9% normal saline. 0.5 mg/kg; i.p.
    References[1] Hernandez-Ilizaliturri FJ, et al. Clin Cancer Res, 2005, 11(16), 5984-5992.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     Pomalidomide 

    Pomalidomide



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