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    Necrostatin-1 (Nec-1)
    Necrostatin-1 (Nec-1)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0037
    CAS #: 4311-88-0Purity ≥98%

    Description: Necrostatin-1 (Nec-1) is a novel, potent and specific RIP1 (receptor-interacting protein 1) kinase inhibitor that inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necroptosis is a cellular mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented. Necrostatin-1, identified as a small-molecule inhibitor of necroptosis, is also a selective allosteric inhibitor of the death domain receptor–associated adaptor kinase RIP1.

    ReferencesStructure. 2013 Mar 5;21(3):493-9; Nat Chem Biol. 2008 May;4(5):313-21. 

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    Molecular Weight (MW)259.33
    CAS No.4311-88-0
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 51 mg/mL warming (196.66 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol: <1 mg/mL (slightly soluble or insoluble)
    SynonymsNecrostatin-1; Necrostatin1; Necrostatin 1; Nec-1; Nec 1; Nec1
    Chemical Name5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one

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    In VitroNecrostatin-1 (1-100 μM) inhibits the autophosphorylation of overexpressed and endogenous RIP1.It is found RIP1 is the primary cellular target responsible for the antinecroptosis activity of Necrostatin-1. Necrostatin-1 efficiently suppresses necroptotic cell death triggered by an array of stimuli in a variety of cell types.
    In VivoNecrostatin-1 (Nec-1) induces tubular bilation and affects the kinetics of the dilation of peritubular capillaries after RCM application. Upon a single intraperitoneal application of a single dose of Necrostatin-1 (1.65 mg/kg body weight, i.p.) 15 minutes before RCM, the return to baseline levels is prevented within the observation period.
    Animal modelMice: 8-10 week old male C57BL/6 mice (average weight approx.23 g) are used. Mice receive intravenous application of 200 μL PBS or radiocontrast media (RCM) via the tail vein. A single dose of Z-VAD-fmk (10 mg/kg body weight) or Necrostatin-1 (1.65 mg/kg body weight) is applied intraperitoneally 15 min. before RCM-injection. Mice are harvested another 24 hours after RCM-application (48 hours after reperfusion). Blood samples are obtained from retroorbital bleeding and serum levels of urea and creatinine are determined.
    Formulation & Dosage1.65 mg/kg; i.p.
    ReferencesDegterev A, et al. Nat Chem Biol, 2005, 1(2), 112-119.J Am Soc Nephrol. 2013 Oct;24(10):1545-57.

    These protocols are for reference only. InvivoChem does not independently validate these methods.





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