Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V30481 | 3'-Hydroxypterostilbene | 475231-21-1 | 3'-Hydroxypterostilbene is an analog of Pterostilbene. |
|
V52505 | 3-Campholenyl-2-butanol | 65113-99-7 | 3-Campholenyl-2-butanol is a synthetic sandalwood odorant that is a selective olfactory receptor OR2AT4 agonist. |
|
V54904 | 3-Hydroxybakuchiol | 178765-54-3 | 3-Hydroxybakuchiol can be extracted from Otholobium mexicanum JW Grimes. |
|
V52501 | 3-Hydroxykynurenine (3-Hydroxy-DL-kynurenine) | 484-78-6 | 3-Hydroxykynurenine is a tryptophan metabolite and a potential endogenous neurotoxin whose expression levels are elevated in several neurodegenerative diseases. |
|
V55017 | 3-O-Methylviridicatin | 6152-57-4 | 3-O-Methylviridicatin is an inhibitor (blocker/antagonist) of TNF-α. |
|
V52499 | 4′-Hydroxywogonin (8-Methoxyapigenin) | 57096-02-3 | 4′-Hydroxywogonin (8-Methoxyapigenin) is a flavonoid that can be extracted from various plants such as Scutellaria barbata and Verbena littoralis. |
|
V52747 | 4-Hydroperoxy Cyclophosphamide-d4 | 1246816-71-6 | 4-Hydroperoxy Cyclophosphamide-d4 is the deuterated form of 4-Hydroperoxy cyclophosphamide. |
|
V54970 | 4-Methylsalicylic acid | 50-85-1 | 4-Methylsalicylic acid is a form of salicylic acid. |
|
V52746 | 4-tert-Octylphenol-3,5-d2 (p-Octylphenol-d2) | 1173021-20-9 | 4-tert-Octylphenol-3,5-d2 is the deuterium labelled form of 4-tert-Octylphenol-3,5. |
|
V56404 | 5'-Methylthioadenosine-13C6 (-(Methylthio)-5'-deoxyadenosine-13C6; 5'-Deoxy-5'-(methylthio)adenosine-13C6; 5'-S-Methyl-5'-thioadenosine-13C6) | 2421187-73-5 | 5'-Methylthioadenosine-13C6 is a 13C (carbon 13)-labeled 5'-Methylthioadenosine. |
|
V56197 | 5'-Methylthioadenosine-d3 (5'-(Methylthio)-5'-deoxyadenosine-d3; 5'-Deoxy-5'-(methylthio)adenosine-d3; 5'-S-Methyl-5'-thioadenosine-d3) | 174838-38-1 | 5'-Methylthioadenosine-d3 is the deuterated form of 5'-Methylthioadenosine. |
|
V30122 | 5,7,4'-Trimethoxyflavone | 5631-70-9 | 5,7,4-Trimethoxyflavone is a naturally occuring flavnoid extracted from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. |
|
V52496 | 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide; 9(11)-DHEP) | 86363-50-0 | 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide), an important steroid from medicinal mushrooms, has anticancer effect against several tumor types. |
|
V56167 | 5-Aminolevulinic acid-13C-1 hydrochloride (5-ALA-13C-1 hydrochloride; δ-Aminolevulinic acid-13C-1 hydrochloride; 5-Amino-4-oxopentanoic acid-13C-1 hydrochloride) | 129720-94-1 | 5-Aminolevulinic acid-13C-1 (5-ALA-13C-1) HCl is a 13C (carbon 13)-labeled 5-Aminolevulinic acid HCl. |
|
V56403 | 5-Aminolevulinic acid-15N hydrochloride (5-ALA-15N hydrochloride; δ-Aminolevulinic acid-15N hydrochloride; 5-Amino-4-oxopentanoic acid-15N hydrochloride) | 116571-80-3 | 5-Aminolevulinic acid-15N ( HCl) is 15N (Nitrogen 15)-labelled 5-Aminolevulinic acid ( HCl). |
|
V52745 | 5-Fluorouracil-13C,15N2 (5-FU-13C,15N2) | 1189423-58-2 | 5-Fluorouracil-13C,15N2 is 13C (carbon 13) and 15N (nitrogen 15) labelled 5-Fluorouracil. |
|
V52744 | 5-Fluorouracil-13C4,15N2 (5-FU-13C4,15N2) | 202407-03-2 | 5-Fluorouracil-13C4,15N2 is 13C (carbon 13) and 15N (nitrogen 15) labelled 5-Fluorouracil. |
|
V52743 | 5-Fluorouracil-15N2 (5-fluorouracil 15N2) | 68941-95-7 | 5-Fluorouracil-15N2 is 15N (Nitrogen 15)-labelled 5-Fluorouracil. |
|
V52742 | 5-Fluorouracil-d (5-FU-d1) | 90344-84-6 | 5-Fluorouracil-d is the deuterated form of 5-Fluorouracil. |
|
V52491 | 5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole) | 191421-10-0 | 5-NIdR (1-(β-D-2-Deoxyribofuranosyl)-5-nitroindole) is an artificial nucleoside with the ability to inhibit the replication of DNA damage produced by Temozolomide . |
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