Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V54844 | 1-Alaninechlamydocin | 141446-96-0 | 1-Alaninechlamydocin is a cyclic tetrapeptide and a potent HDAC inhibitor (IC50=6.4 nM). |
|
V54831 | 1-Decarboxy-3-oxo-ceanothic acid (DOCA) | 214150-74-0 | 1-Decarboxy-3-oxo-ceanothic Acid is an anti-cancer compound. |
|
V52956 | 10-Formyl-5,8-dideazafolic acid | 61038-31-1 | 10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor. |
|
V52524 | 12-HETE (12-hydroxyeicosatetraenoic acid) | 71030-37-0 | 12-HETE is the major metabolite of arachidonic acid catalyzed by 12-LOX and inhibits cell apoptosis. |
|
V52754 | 12-HETE-d8 | 2525175-25-9 | 12-HETE-d8 is the deuterated form of 12-HETE. |
|
V54906 | 142I5 | 2865171-75-9 | 142I5 is a potent covalent/irreversible inhibitor of ML-IAP Lys with IC50 of 11 nM. |
|
V56434 | 2'-epi-2'-O-Acetylthevetin B (GHSC-74) | 82145-55-9 | 2'-epi-2'-O-Acetylthevetin B (GHSC-74) is a cardiac glycoside that can be extracted from the seeds of Cerbera manghas L. |
|
V52508 | 2'-Fucosyllactose (2'-FL) | 41263-94-9 | 2'-Fucosyllactose (2'-FL) is an oligosaccharide found in breast milk. |
|
V52987 | 2'-O-Methylguanosine | 2140-71-8 | 2'-O-Methylguanosine is a modified nucleoside generated by tRNA guanosine-2'-o-methyltransferase. |
|
V54912 | 2,3-DCPE | 418788-90-6 | 2,3-DCPE can cause apoptosis and downregulate Bcl-XL expression. |
|
V52520 | 2,4,6-Triiodophenol (2,4,6-Triiodophenol) | 609-23-4 | 2,4,6-Triiodophenol is an orally bioactive, potent inhibitor of leukotriene B4 (LTB4) synthesis. |
|
V2808 | 2-Bromohexadecanoic acid (2-Bromopalmitic acid) | 18263-25-7 | 2-Bromohexadecanoic acid (2-Bromopalmitic acid) is a 2-bromopalmitic acid that can be converted to 2-bromopalmitate (2-BP). |
|
V54888 | 2-Chlorophenoxazine | 56821-03-5 | 2-Chlorophenoxazine is an Akt inhibitor (antagonist) with an in vitro IC50 of 2-5 μM. |
|
V54913 | 2-Hydroxy-3-methylanthraquinone (emodin impurity 16) | 17241-40-6 | 2-Hydroxy-3-methylanthraquinone (compound 1) is extracted from the aqueous extract of Hephiphylla alba. |
|
V54861 | 2-Hydroxycinnamaldehyde | 3541-42-2 | 2-Hydroxycinnamaldehyde is a phenylpropanoid that can be extracted from the bark of Cinnamomum cassia. |
|
V56422 | 2-Methoxyestradiol-13C,d3 (Dimethoxyestradiol 13C,d3) | 1217470-09-1 | 2-Methoxyestradiol-13C,d3 is a 13C- and deuterium labelled 2-Methoxyestradiol. |
|
V54859 | 2-tert-Butyl-1,4-benzoquinone | 3602-55-9 | 2-tert-Butyl-1,4-benzoquinone is the electrophilic metabolite of butylated hydroxyanisole and the oxidation product of 2-tert-butylhydroquinone. |
|
V4717 | Aloperine | 56293-29-9 | Aloperine is an alkaloid found in the roots ofS. |
|
V53142 | 23-Hydroxybetulinic acid (23-hydroxybetulinic acid; Anemosapogenin) | 85999-40-2 | 23-hydroxybetulinic acid is a biological compound with anti-cancer effect. |
|
V52515 | 28-Deoxonimbolide | 126005-94-5 | 28-Deoxonimbolide is a nimbin limonoid that can be extracted from Azadirachta indica seed extract. |
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