Cell membrane blebbing, chromatin condensation, genomic DNA fragmentation, and the exposure of particular phagocytosis signaling molecules on the cell surface are just a few of the distinctive morphological and biochemical features of the cell death process known as apoptosis. Apoptosis-initiated cell death is distinct from necrosis-induced cell death. Apoptotic death, in contrast, is silent and orderly. Necrotic cells are typically recognized as a danger signal by the immune system, which causes inflammation.
There are two main methods for inducing apoptotic cell death: The intrinsic pathway, also known as the Bcl-2-regulated or mitochondrial pathway, is strictly regulated by the BCL-2 family of proteins and is activated by a variety of developmental cues or cytotoxic insults, such as viral infection, DNA damage, and growth-factor deprivation.The tumor necrosis factor (TNF) receptor family members, such as Fas or TNF receptor-1 (TNFR1), which contain an intracellular death domain and can recruit and activate caspase-8 through the adaptor protein Fas-associated death domain (FADD; also known as MORT1) at the cell surface, are what initiate the extrinsic or death-receptor pathway. Without the involvement of the BCL-2 family, this recruitment results in the subsequent activation of downstream (effector) caspases like caspase-3, -6, or -7.
Numerous human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome), may be influenced by changes in cell survival, according to studies. Some of these diseases may not progress naturally unless specific therapies that change the apoptotic threshold are used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V52489 | 6,8-Diprenylorobol (6,8-Diprenylcoupeagen) | 66777-70-6 | 6,8- diprenylorobol is an enoylated isoflavone, a naturally occurring compound extracted from the leaves of Cudrania tricuspidata. |
|
V52485 | 6-Dehydrogingerdione | 76060-35-0 | 6-Dehydrogingerdione sensitizes human hepatoblastoma Heg2 cells to TRAIL-induced apoptosis through the increase of DR5 mediated by reactive oxygen species. |
|
V52482 | 6-Formylpterin | 712-30-1 | 6-Formylpterin is an inhibitor (blocker/antagonist) of Xanthine Oxidase. |
|
V54837 | 7,3′,5′-Trihydroxyflavanone | 847375-46-6 | 7,3′,5′-Trihydroxyflavanone is a flavonoid analogue that can cause apoptosis in MCF-7 cells by increasing Bax expression levels. |
|
V54858 | 7-epi-Isogarcinol | 1141378-40-6 | 7-epi-Isogarcinol is a polycyclic polyprenoylphloroglucinol (PPAP) with moderate antiproliferation activity. |
|
V54853 | 7-Ketositosterol | 2034-74-4 | 7-Ketositosterol is a phytosterol extracted from the fruits of the mulberry tree (Morus alba L.). |
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V52478 | 7-Methoxy-1-tetralone | 6836-19-7 | 7-Methoxy-1-tetralone is a potent antineoplastic/anticancer agent. |
|
V52469 | 8-Aminoadenosine (8-Aminoadenosine; 8-NH2-Ado) | 3868-33-5 | 8-Aminoadenosine (8-NH2-Ado) is an RNA-directed nucleoside analog that reduces cellular ATP levels and inhibits mRNA synthesis. |
|
V52472 | 8-Epixanthatin | 30890-35-8 | 8-Epixanthatin is a potential colchicine binding site inhibitor extracted from Xanthium chinese Mill. |
|
V52475 | 84-B10 | 698346-43-9 | 84-B10 is a 3-phenylglutaric acid analogue. |
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V54927 | A-1293102 | 1565759-96-7 | A-1293102 is a potent and specific BCL-XL inhibitor that kills BCL-XL-dependent tumor cells. |
|
V77704 | A-71915 TFA | A-71915 (TFA) is a selective atrial natriuretic peptide receptor (ANP receptor) inhibitor that can cause apoptosis of RINm5F pancreatic β-cells and reduce insulin secretion. | |
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V54941 | A09-003 | 2911646-14-3 | A09-003 is a CDK-9 inhibitor (IC50= 16 nM). |
|
V52462 | A947 | 2378056-80-3 | A947 is a potent and specific SMARCA2 proteolytically targeting chimeric molecule (PROTAC). |
|
V52460 | AAF-CMK | 102129-66-8 | AAF-CMK is a TPPII (tripeptidylpeptidase II) inhibitor that has anti-tumor activity and causes apoptosis. |
|
V52663 | Abacavir-d4 (Abacavir d4) | 1260619-56-4 | Abacavir-d4 is the deuterium labelled form of Abacavir. |
|
V53116 | ABBV-167 | 1351456-78-4 | ABBV-167 is a phosphate precursor of the BCL-2 inhibitor venetoclax. |
|
V54884 | ABL-L | 1613152-39-8 | ABL-L causes apoptosis in human laryngeal cancer/tumor cells through a p53-dependent pathway. |
|
V9987 | ABT-510 TFA salts | 251579-55-2 | ABT-510 TFA, the trifluoroacetic acid (TFA) salt form of ABT-510 which is a TSP-1 mimetic drug,is a synthetic peptide composed of nine-amino acids, it acts bymimicking the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). |
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V54963 | Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) | 201608-15-3 | Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) is a potent and reversible caspase-3 inhibitor. |
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