| Size | Price | Stock | Qty |
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| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
| Targets |
The primary targets of 2,4,6-Triiodophenol are not biological, as it is not a drug. It is used as a chemical intermediate. However, its derivatives may have biological activity, such as antimicrobial properties. The compound itself may interact with proteins through iodination, but this is not a therapeutic target.
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| ln Vitro |
The quality of pre-implantation mouse embryos is affected by 2,4,6-triiodophenol (5-50 μM; 0-100 h) in a dose-dependent way, leading to a decrease in the number of total and trophectoderm cells[2]. In mouse pre-implantation embryos, 2,4,6-triiodophenol (5 μM; 85 h) increases the number of apoptotic cells[2]. In mouse pre-implantation embryos, 2,4,6-triiodophenol (5–50 μM; 100 h) causes oxidative stress[2].
In vitro, 2,4,6-Triiodophenol is used as a reagent for iodination reactions. It is not typically tested for biological activity. Its derivatives, such as iopanoic acid or iothiouracil, are used as contrast agents or antimicrobials. The compound may exhibit some antimicrobial activity due to its iodine content. |
| ln Vivo |
In vivo, the compound itself is not administered. Its derivatives are used in diagnostic imaging (e.g., X-ray contrast agents) and as antifungal agents. The parent compound is not intended for therapeutic use.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays are not applicable to this compound. Quality control assays include HPLC, melting point determination, and elemental analysis to confirm purity and iodine content. The compound is tested for solubility and stability.
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| Cell Assay |
Apoptosis Analysis[2]
Cell Types: Mouse blastocyst cells Tested Concentrations: 5 μM Incubation Duration: 85 hrs (hours) Experimental Results: demonstrated signals of activated Caspase-3/7. Immunofluorescence[2] Cell Types: Mouse blastocyst cells Tested Concentrations: 5-50 μM Incubation Duration: 100 hrs (hours) Experimental Results: Resulted in marked increase of oxygen species (ROS) treated with high dose of 2,4,6-Triiodophenol. In vitro cellular assays are not performed with this compound, as it is not a drug candidate. It may be used in cell culture as a source of iodine for certain experiments, but this is rare. |
| Animal Protocol |
In vivo animal studies are not conducted with 2,4,6-Triiodophenol itself. Its derivatives may be tested for toxicity and efficacy in animal models.
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| ADME/Pharmacokinetics |
2,4,6-Triiodophenol has a molecular formula of C6H3I3O and a molecular weight of 471.80. It appears as a solid with a melting point of 155-158°C. It is soluble in organic solvents such as ethanol and ether, but sparingly soluble in water. The compound should be stored in a cool, dry place, protected from light. It is intended for research use only and is not for human consumption.
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| Toxicity/Toxicokinetics |
The toxicity profile of 2,4,6-Triiodophenol is characterized by its iodine content. It may cause skin and eye irritation. It is not classified as a carcinogen. Standard safety precautions should be followed. It is not approved for clinical use.
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| References |
[1]. Liu S, et al. 2,4,6-triiodophenol exhibits embryotoxicity to pre-implantation mouse embryos in an in vitro exposure model. Ecotoxicol Environ Saf. 2022 Aug;241:113745.
[2]. Trocóniz IF, et al. Dealing with time-dependent pharmacokinetics during the early clinical development of a new leukotriene B4 synthesis inhibitor. Pharm Res. 2006 Jul;23(7):1533-42. |
| Additional Infomation |
2,4,6-Triiodophenol (CAS 609-23-4) is an iodinated phenol derivative used as a precursor in the synthesis of diagnostic imaging agents and other iodinated compounds. It has a molecular formula of C6H3I3O and a molecular weight of 471.80. It is also used as a disinfectant and in organic synthesis. It is not intended for therapeutic use and is for research and industrial purposes only.
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| Molecular Formula |
C6H3I3O
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|---|---|
| Molecular Weight |
471.8008
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| Exact Mass |
471.731
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| CAS # |
609-23-4
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| PubChem CID |
11862
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| Appearance |
Off-white to pink solid powder
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| Density |
3.1±0.1 g/cm3
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| Boiling Point |
316.3±42.0 °C at 760 mmHg
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| Melting Point |
157-159 °C(lit.)
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| Flash Point |
145.1±27.9 °C
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
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| Index of Refraction |
1.816
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| LogP |
3.88
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
10
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| Complexity |
108
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| Defined Atom Stereocenter Count |
0
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| SMILES |
IC1C([H])=C(C([H])=C(C=1O[H])I)I
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| InChi Key |
VAPDZNUFNKUROY-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H3I3O/c7-3-1-4(8)6(10)5(9)2-3/h1-2,10H
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| Chemical Name |
2,4,6-triiodophenol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : 250 mg/mL (529.89 mM)
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|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1195 mL | 10.5977 mL | 21.1954 mL | |
| 5 mM | 0.4239 mL | 2.1195 mL | 4.2391 mL | |
| 10 mM | 0.2120 mL | 1.0598 mL | 2.1195 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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