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    Dibucaine HCl (Cinchocaine)
    Dibucaine HCl (Cinchocaine)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1667
    CAS #: 61-12-1Purity ≥98%

    Description: Dibucaine HCl (also known as Cinchocaine), a sodium channel inhibitor, is one of the most potent and toxic of the long-acting local anesthetics. Dibucaine is the active ingredient in some topical hemorrhoid creams such as Proctosedyl. It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle. Dibucaine HCl blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.

    References: Biochim Biophys Acta. 1987 May 29;899(2):196-204; Biochim Biophys Acta. 1987 May 29;899(2):196-204.


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    Molecular Weight (MW)379.92 
    FormulaC20H29N3O2.HCl 
    CAS No.61-12-1 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 76 mg/mL (200.0 mM)
    Water: 76 mg/mL (200.0 mM)
    Ethanol: 76 mg/mL (200.0 mM)
    Other info

    Chemical Name: 2-Butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide hydrochloride

    InChi Key: IVHBBMHQKZBJEU-UHFFFAOYSA-N

    InChi Code: InChI=1S/C20H29N3O2.ClH/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3;/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24);1H

    SMILES Code: O=C(C1=CC(OCCCC)=NC2=CC=CC=C12)NCCN(CC)CC.[H]Cl           

    SynonymsCinchocaine HCl; Dibucaine HCl; Cinchocaine hydrochloride; Cincaine chloride; Cincain; Nupercainal; Nupercaine; Sovcaine


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    In Vitro

    In vitro activity: Dibucaine (Cinchocaine) HCl is one of the most potent and toxic of the long-acting local anesthetics. Dibucaine (Cinchocaine) HCl blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.

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    References

    Biochim Biophys Acta. 1987 May 29;899(2):196-204; Biochim Biophys Acta. 1987 May 29;899(2):196-204. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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