Sodium channels are membrane proteins that function as ion channels and transport sodium ions (Na+) across the plasma membrane of cells. They are divided into two categories based on what opens the channel for these ions: voltage changes (for voltage-gated, voltage-sensitive, or voltage-dependent sodium channels, also known as VGSCs or Nav channels), or ligand bindings (for ligand-gated sodium channels). The rising phase of action potentials is caused by sodium channels in excitable cells like neurons, myocytes, and some varieties of glia. There are three different states of voltage-gated Na+ channels: deactivated (closed), activated (open), and inactivated (closed). Instead of a change in membrane potential, ligand-gated sodium channels are activated by the binding of a ligand.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73712 | ATX-II | 60748-45-0 | ATX-II is a specific Na+ channel modulator toxin found in the venom of the sea anemone (Anemonia sulcata). |
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V78287 | ATX-II TFA | ATX-II TFA is a specific Na+ channel modulator toxin found in the venom of the sea anemone (Anemonia sulcata). | |
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V78362 | BDS-II | BDS-II is a bioactive peptide toxin consisting of 43 amino acid (AA)s. | |
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V37989 | Benzamil | 2898-76-2 | Benzamil is an Amiloride analogue acting as aNa+/Ca2+ exchanger (NCX) inhibitor(IC50~100 nM) with the potential to treat cystic fibrosis. |
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V1656 | Benzocaine | 94-09-7 | Benzocaine (H-4-Abz-OEt; NSC-4688; NSC-41531; tradename Orajel among others), the ethyl ester of p-aminobenzoic acid (PABA), is a local anesthetic that has been widely used as a topical pain reliever or in cough drops. |
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V73698 | Benzocaine-(ethyl-d5) (Benzocaine d5) | 1219803-76-5 | Benzocaine-(ethyl-d5) is the deuterated form of Benzocaine. |
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V73723 | Benzocaine-d4 (Benzocaine d4) | 342611-08-9 | Benzocaine-d4 is the deuterium labelled form of Benzocaine. |
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V4051 | BI-01383298 | 2227549-00-8 | BI01383298 (also known as BI-01383298) is a potent, specific/selective inhibitor of human SLC13A5 (Na+/citrate co-transporter) with IC50of 56 nM in HEK cells overexpressing hSLC13A5 and 24 nM in HepG2 cells with endogenous SLC13A5 expression. |
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V73664 | Bifenthrin (bifenthrin) | 82657-04-3 | Bifenthrin is a synthetic pyrethroid insecticide. |
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V73679 | Bliretrigine | 1233229-75-8 | Bliretrigine is a sodium channel blocker. |
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V78490 | BmK-M1 | BmK-M1 is a scorpion toxin consisting of 64 amino acid (AA)s cross-linked by four disulfide bridges. | |
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V73702 | Brevetoxin B (Brevetoxin-2; PbTx-2) | 79580-28-2 | Brevetoxin B (Brevetoxin-2) is a polyketide neurotoxin (neurotoxin) produced by Karenia species or other dinoflagellates. |
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V3961 | Bulleyaconitine A | 107668-79-1 | Bulleyaconitine A (also known as Bulleyaconi cine A) is a potent analgesic and antiinflammatory drugisolated from aconitum plant displays long-acting local anesthetic properties in vitro and in vivo. |
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V1642 | Bupivacaine HCl (HSDB 7790) | 18010-40-7 | Bupivacaine HCl (AH250; HSDB7790; SKY0402; AH-250;Win-11318;HSDB-7790;SKY-0402; Marcaine),the hydrochloride salt ofBupivacaine, is a potent inhibitor of cAMP production that alsobinds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells. |
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V78608 | Calcitriol-13C3 (1,25-Dihydroxyvitamin D3-13C3) | Calcitriol-13C3 is a 13C (carbon 13)-labeled Calcitriol. | |
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V1660 | Camostat Mesilate (FOY305) | 59721-29-8 | Camostat mesylate (also known as FOY-305; FOY-S980), the mesylate salt of Camostat, is a potent and orally bioactive trypsin-like protease inhibitor with potential antifibrotic activity. |
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V14513 | Cariporide | 159138-80-4 | Cariporide (HOE-642) is a selective Na+/H+ exchange inhibitor. |
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V78725 | Ceratotoxin-1 (CcoTx1; β-TRTX-cm1a) | Ceratotoxin-1 (CcoTx1) is a bioactive peptide toxin and inhibitor of voltage-gated sodium channel subtypes. | |
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V73682 | Ceratotoxin-2 (CcoTx2; β-TRTX-cm1b) | 880885-98-3 | Ceratotoxin-2 (CcoTx2) is a voltage-gated sodium channel blocker with IC50s of 8 nM and 88 nM for Nav1.2/β1 and Nav1.3/β1, respectively. |
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V11883 | Chlorthalidone | 77-36-1 | Chlorthalidone (Phthalamodine; Thalitone;Oxodoline; Phthalamudine) is a potent thiazidediuretic drugused to treat hypertension. |
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