Size | Price | Stock | Qty |
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10mg |
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25mg |
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50mg |
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100mg |
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Purity: ≥98%
This product has been discontinued. Verdinexor (formerly KPT-335; KPT 335; KPT335) is an orally bioavailable, selective XPO1/CRM1 (Exportin 1/Chromosomal Maintenance 1) inhibitor with potential antineoplastic activity. Verdinexor inhibited proliferation, blocked colony formation, and induced apoptosis of treated cells at biologically relevant concentrations of drug. Additionally, Verdinexor downregulated XPO1 protein while inducing a concomitant increase in XPO1 messenger RNA. Verdinexor treatment of cell lines upregulated the expression of both protein and mRNA for the tumor suppressor proteins p53 and p21, and promoted their nuclear localization.
ln Vitro |
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ln Vivo |
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Animal Protocol |
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References |
J Virol.2014 Sep 1;88(17):10228-43;Am J Physiol Renal Physiol.2014 Dec 1;307(11):F1179-86.
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Molecular Formula |
C18H12F6N6O
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Molecular Weight |
442.32
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CAS # |
1392136-43-4
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SMILES |
O=C(NNC1=NC=CC=C1)/C=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.2608 mL | 11.3040 mL | 22.6081 mL | |
5 mM | 0.4522 mL | 2.2608 mL | 4.5216 mL | |
10 mM | 0.2261 mL | 1.1304 mL | 2.2608 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.