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    Nicorandil (SG-75)
    Nicorandil (SG-75)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1676
    CAS #: 65141-46-0Purity ≥98%

    Description: Nicorandil (also known as RP-46417, SG-75, and Adancor) is a potassium channel activator, which stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP). Nicorandil is a vasodilatory drug used to treat angina. Nicorandil causes vasodilatation of arterioles and large coronary arteries. Nicorandal's nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase. 

    References: J Am Coll Cardiol. 2000 Feb;35(2):514-8; Mol Cell Biochem. 2003 Jan;243(1-2):133-8.

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    Molecular Weight (MW)211.17
    CAS No.65141-46-0
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 42 mg/mL (198.9 mM)
    Water: 17 mg/mL (80.5 mM)
    Ethanol: 42 mg/mL (198.9 mM)
    Other info

    Chemical Name: 2-(nicotinamido)ethyl nitrate


    InChi Code: InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)

    SMILES Code: O=[N+]([O-])OCCNC(C1=CN=CC=C1)=O

    SynonymsSG-75; RP-46417; SG 75; RP-46417; SG75; RP-46417; Adancor; Dancor

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    In Vitro

    In vitro activity: Nicorandil (100 mM) increases Flavoprotein oxidation but not membrane current; a 10-fold higher concentration recruits both mitoK(ATP) and surfaceK(ATP) channels. Nicorandil bluntes the rate of cell death in a pelleting model of ischemia; this cardioprotective effect is prevented by the mitoK(ATP) channel blocker 5-hydroxydecanoate but is unaffected by the surfaceK(ATP) channel blocker HMR1098. Nicorandil (100 mM) suppresses TUNEL positivity, cytochrome c translocation, caspase-3 activation and dissipation of mitochondrialinner membrane potential (Delta(Psi)(m)). Nicorandil prevents Delta(Psi)(m) depolarization in a concentration-dependent manner (EC(50) approximately 40 mM, with saturation by 100 mM), as shown by fluorescence-activated cell sorter analysis of cells stained with a fluorescent Delta(Psi)(m)-indicator, tetramethylrhodamine ethyl ester (TMRE). Nicorandil activates a weakly inwardly-rectifying, glibenclamide-sensitive 80 pS K+ channel in both the transfected cells. Nicorandil preferentially activates the K(ATP) channels containing SUR2B in HEK293T cells. Nicorandil (100 mM) significantly suppresses the number of cells with TUNEL-positive nuclei and the increase in caspase-3 activity induced by 20 mM H2O2. Nicorandil prevents the loss of DeltaPsim induced by H2O2 in a concentration-dependent manner.

    In VivoNicorandil (2.5 mg/kg daily, p.o.) combined with Amlodipine (5.0 mg/kg daily, p.o.) for 3 days significantly prevents these alterations and restored the enzyme activities to near normal in rats.
    Animal modelRats
    Formulation & Dosage2.5 mg/kg daily, p.o.

    J Am Coll Cardiol. 2000 Feb;35(2):514-8; Mol Cell Biochem. 2003 Jan;243(1-2):133-8.

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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