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    InvivoChem Cat #: V1696
    CAS #: 175135-47-4Purity ≥98%

    Description: O4I1 is a novel and potent inducer of Oct3/4 and can enhance Oct3/4 expression. Oct3/4 is specifically expressed in the ES cells, epiblast, preimplantation embryos, and germ cells, et al. O4I1 not only promoted expression and stabilization of Oct3/4 but also enhanced its transcriptional activity in diverse human somatic cells, implying the possible benefit from using this class of compounds in regenerative medicine. 

    References: J Med Chem. 2015 Jun 25;58(12):4976-83.

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    Molecular Weight (MW)253.30
    CAS No.175135-47-4
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 51 mg/mL (201.3 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 4-[(4-Methoxyphenyl)methoxy]benzeneacetonitrile


    InChi Code: InChI=1S/C16H15NO2/c1-18-15-6-4-14(5-7-15)12-19-16-8-2-13(3-9-16)10-11-17/h2-9H,10,12H2,1H3



    O4I1; O4I-1; O4I 1

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    In Vitro

    In vitro activity: O4I1 enhances Oct3/4 gene expression by approximately 2.5- and 4-fold at 10 μM and 20 μM, respectively, increases Oct3/4 protein levels, and promotes Oct3/4 mediated transcriptional activation.

    Cell Assay: When treated the synthesized cDNA from RNA isolated from the HEK293 cells with 10 µM and 20 µM O4I1 for 72 hrs, the Oct3/4 mRNA levels increased about 2.5- and 4-fold respectively. In human adult primary fibroblast (HF) and human neonatal foreskin fibroblast (HFF) cell lines, treatment with 10 µM O4I1 increased the gene and protein expression level of Oct3/4 after 72 hrs incubation in HF cells and 7 days in HFF cells. The derivatives of O4I1 such as compound 2, showed a time-dependent activation of Oct3/4 and markedly elevated the efficiency of Oct3/4 induction.

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    J Med Chem. 2015 Jun 25;58(12):4976-83.

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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