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    O4I2
    O4I2

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1695
    CAS #: 165682-93-9Purity ≥98%

    Description: O4I2 is a novel and potent Oct3/4 inducer, which is suitable for iPSC generation. O4I2 shows high activity in enforcing Oct3/4 expression. O4I2 activates Oct3/4 on the transcriptional and translational level in human fibroblasts. O4I2 promotes the expression of pluripotency-associated genes as analyzed by qRT-PCR in human neonatal foreskin fibroblasts (HFFs). O4I2 markedly stimulates Oct3/4 even at 5 μM after 72 h treatment on the translational level.

    References: J Med Chem. 2015 Aug 13;58(15):5742-50.

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    Molecular Weight (MW)282.75
    FormulaC12H11ClN2O2S
    CAS No.165682-93-9
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 56 mg/mL (198.1 mM)
    Water: <1 mg/mL
    Ethanol: 20 mg/mL (70.7 mM)
    Other info

    Chemical Name: ethyl 2-((4-chlorophenyl)amino)thiazole-4-carboxylate

    InChi Key: ULUBAPWNHROTEU-UHFFFAOYSA-N

    InChi Code: InChI=1S/C12H11ClN2O2S/c1-2-17-11(16)10-7-18-12(15-10)14-9-5-3-8(13)4-6-9/h3-7H,2H2,1H3,(H,14,15)

    SMILES Code: O=C(C1=CSC(NC2=CC=C(Cl)C=C2)=N1)OCC

    Synonyms

    O4I2; O-4I2; O4I-2


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    In Vitro

    In vitro activity: O4I2 activates Oct3/4 expression in HEK293 and embryonal NCCIT cells, and also in Oct-deficient HeLa and terminally differentiated human fibroblasts, and also induces other pluripotency-associated genes such as Lin28 and Nanog.

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    References

    J Med Chem. 2015 Aug 13;58(15):5742-50.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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