The central nervous system contains a family of enzymes known as cholinesterase (ChE), which catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid. This reaction is required for cholinergic neurons to return to their resting state after activation. It is one of many crucial enzymes required for the healthy operation of human nervous systems.
There are two: butyrylcholinesterase (BChE, acylcholine acylhydrolase), also referred to as nonspecific cholinesterase or pseudocholinesterase, and acetylcholinesterase (AChE, acetylcholine hydrolase). While BChE is made in the liver and is mainly found in plasma, AChE is mainly found in the blood on the membranes of red blood cells, at neuromuscular junctions, and in neural synapses. The relative substrate preferences of the two types of cholinesterase are different: AChE hydrolyzes acetylcholine more quickly while BChE hydrolyzes butyrylcholine more quickly.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V79692 | hAChE-IN-4 | hAChE-IN-4 (Compd 5d) is a potent, BBB (blood-brain barrier)-passing hAChE inhibitor (antagonist) with IC50 of 0.25 μM. | |
|
V79886 | hAChE-IN-6 | hAChE-IN-6 (compound 51) is an AChE inhibitor that crosses the BBB (blood-brain barrier) with IC50 of 0.16 μM. | |
|
V71425 | hAChE/Aβ1-42-IN-1 | 2761149-17-9 | hAChE/Aβ1-42-IN-1 (Compound 16) is a potent inhibitor of hAChE and Aβ1-42 aggregation. |
|
V79689 | hAChE/hBACE-1-IN-1 | hAChE/hBACE-1-IN-1 (compounds 5d) is an orally bioactive inhibitor of hAChE with blood-brain permeability. | |
|
V71602 | hBChE-IN-2 | 2923366-36-1 | hBChE-IN-2 (compound 15d) is a butyrylcholinesterase (BChE) inhibitor (IC50 of 0.62 μM) and cannabinoid receptor 2 (CB2R) agonist. |
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V71664 | Heliosupine | 32728-78-2 | Heliosupine is a pyrrolidine alkaloid. |
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V71677 | Huperzine C | 163089-71-2 | Huperzine C is an alkaloid extracted from Huperzia serrate. |
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V71668 | Hydrangenol 8-O-glucoside (Hydrangenol 8-O-β-D-glucopyranoside) | 67600-94-6 | Hydrangenol 8-O-glucoside (Hydrangenol 8-O-β-D-glucopyranoside) can be extracted from Hydrangea macrophyllu. |
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V80185 | Insecticidal agent 5 | Insecticidal agent 5 (compound 8) is an AChE-targeting insecticide with an LD50 of 27.65 ppm against cotton leafworm Spodoptera littoralis. | |
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V71624 | Ipidacrine (Ipidacrine) | 62732-44-9 | 2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b]quinolin-9-amine is a bioactive compound that is a nootropic and works as a cholinesterase inhibitor. |
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V71702 | Isograndifoliol | 1445475-53-5 | Isograndifoliol is a selective butyrylcholinesterase (BChE) inhibitor (antagonist) with IC50 of 0.9 μM. |
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V80406 | Isoimperatorin-d6 (isoimperatorin-d6) | Isoimperatorin-d6 is the deuterium labelled form of Isoimperatorin. | |
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V71652 | Isonaringin | 108815-81-2 | Isonaringin exerts anti-Alzheimer's activity through inhibition of AChE. |
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V71701 | K027 | 6586-37-4 | K027 potently reactivates organophosphate (OP)-inhibited acetylcholinesterase (AChE) activity. |
|
V80476 | K1833 | K1833 is an hrAChE inhibitor/reactivator with IC50 of 58 μM. | |
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V71635 | Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) | 25615-14-9 | Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) is a flavonol active in α-amylase, α-glucosidase and acetylcholine Acetylcholinesterase has enzyme inhibitory effect. |
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V24160 | Linarin | 480-36-4 | Linarin (Buddleoside) is extracted from peppermint flower extract and selectively inhibits acetylcholinesterase (AChE). |
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V71708 | Lycodoline (lycodoline) | 6900-92-1 | Lycodoline is an alkaloid with inhibitory activity against butyrylcholinesterase (BChE) (IC50 of 667 μM). |
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V71656 | Manghaslin (Quercetin-3-O-rutose-(1→2)-O-rhamnoside) | 55696-57-6 | Manghaslin is a flavonoid glycoside with anti~inflammatory activity. |
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V79953 | MAO-B-IN-24 | MAO-B-IN-24 (compound 11h) is a selective, reversible, competitive inhibitor of MAO-B (IC50= 1.60 μM). |
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