The central nervous system contains a family of enzymes known as cholinesterase (ChE), which catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid. This reaction is required for cholinergic neurons to return to their resting state after activation. It is one of many crucial enzymes required for the healthy operation of human nervous systems.
There are two: butyrylcholinesterase (BChE, acylcholine acylhydrolase), also referred to as nonspecific cholinesterase or pseudocholinesterase, and acetylcholinesterase (AChE, acetylcholine hydrolase). While BChE is made in the liver and is mainly found in plasma, AChE is mainly found in the blood on the membranes of red blood cells, at neuromuscular junctions, and in neural synapses. The relative substrate preferences of the two types of cholinesterase are different: AChE hydrolyzes acetylcholine more quickly while BChE hydrolyzes butyrylcholine more quickly.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V76784 | Mca-YVADAP-Lys(Dnp)-OH TFA | Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and ACE (angiotensin-converting enzyme) 2 (ACE2). | |
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V71686 | Methyl ganoderate A acetonide | 1346453-53-9 | Methyl ganoderate A acetonide, a lanosterane triterpenoid compound, is a naturally occurring compound that can be extracted from the fruiting bodies of Ganoderma lucidum. |
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V78663 | Millmerranone A | Millmerranone A has properties that inhibit acetylcholinesterase. | |
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V18202 | ML352 | 1649450-12-3 | ML352 is a noncompetitive inhibitor of the presynaptic choline transporter (CHT) with Kis of 92 nM and 166 nM for HEK293 cells expressing human CHT and mouse forebrain synaptosomes, respectively. |
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V71694 | Monarsen (EN101; ODN 7040; BL 7040) | 864021-55-6 | Monarsen (EN101) is an antisense oligonucleotide targeting the human AChE gene. |
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V80807 | Monarsen sodium (EN101 sodium; ODN 7040 sodium; BL 7040 sodium) | Monarsen sodium is an antisense oligonucleotide targeting the human AChE gene. | |
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V71663 | Monocrotophos-d6 | 1795136-77-4 | Monocrotophos-d6 is a deuterium-labeled Monocrotophos. |
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V82222 | N-Boc-piperazine-C3-COOH | 959053-53-3 | N-Boc-piperazine-C3-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker that may be utilized to prepare PROTAC PD-1/PD-L1 degrader-1 . |
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V71620 | N-Desmethyl Galanthamine (N-Norgalanthamine) | 41303-74-6 | N-Desmethyl Galanthamine is a metabolite of Galanthamine. |
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V71675 | N-Methylcalycinine | 86537-66-8 | N-Mmethylcalycinine is a naturally occurring compound with AChE inhibitory activity. |
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V71618 | O-Desmethyl Galanthamine (Sanguinine) | 60755-80-8 | O-Desmethyl Galanthamine (Sanguinine) is a galantamine-type alkaloid. |
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V71654 | Octahydroaminoacridine | 13415-07-1 | OctaHydraminoacridine is a Tacrine analogue and a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). |
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V71647 | Osmanthuside B | 94492-23-6 | Osmanthuside B can be extracted from Pseuderanthemum carruthersii (Seem. |
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V71682 | P11149 | 164724-79-2 | P11149 is an analogue of Galanthamine. |
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V71634 | Paecilomide | 1538575-22-2 | Paecilomide, a pyridone alkaloid, is an acetylcholinesterase inhibitor. |
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V81055 | PD07 | PD07 is an orally bioactive AChE inhibitor (IC50= 0.29 μM for hAChE). | |
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V81057 | PD10 | PD10 is an AChE and BuChE inhibitor (hAChE IC50= 0.56 μM; eeAChE IC50= 0.59 μM; eqBuChE IC50= 1.06 μM). | |
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V79094 | PD24 | PD24 is an AChE and BuChE inhibitor (hAChE IC50= 1.72 μM; eeAChE IC50= 1.76 μM; eqBuChE IC50= 2.64 μM). | |
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V79004 | PD25 | PD25 is an AChE and BuChE inhibitor (hAChE IC50= 1.58 μM; eeAChE IC50= 1.63 μM; eqBuChE IC50= 2.39 μM). | |
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V71676 | Picfeltarraegenin | 1391826-61-1 | Picfeltarraenin X is a triterpenoid and an AChE inhibitor. |
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