ChE

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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ChE

The central nervous system contains a family of enzymes known as cholinesterase (ChE), which catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid. This reaction is required for cholinergic neurons to return to their resting state after activation. It is one of many crucial enzymes required for the healthy operation of human nervous systems.
There are two: butyrylcholinesterase (BChE, acylcholine acylhydrolase), also referred to as nonspecific cholinesterase or pseudocholinesterase, and acetylcholinesterase (AChE, acetylcholine hydrolase). While BChE is made in the liver and is mainly found in plasma, AChE is mainly found in the blood on the membranes of red blood cells, at neuromuscular junctions, and in neural synapses. The relative substrate preferences of the two types of cholinesterase are different: AChE hydrolyzes acetylcholine more quickly while BChE hydrolyzes butyrylcholine more quickly.

ChE related products

Cat No.	Product Name	CAS No.	Product Description
V70437	Bis(7)-tacrine dihydrochloride	224445-12-9	Bis(7)-tacrine di-HCl is a dimeric acetylcholinesterase (AChE) inhibitor found in tacrine.
V78055	Bis-(-)-8-demethylmaritidine		Bis-(-)-8-demethylmaritidine is a naturally occurring alkaloid and a potent acetylcholinesterase (AChE) inhibitor.
V71707	Broussonin A	73731-87-0	Broussonin A is a potent BChE inhibitor (antagonist) with IC50 of 4.16 µM.
V78865	BuChE-IN-7		BuChE-IN-7 is a selective inhibitor of hBuChe and eqBuChE with IC50 of 40 nM and 80 nM respectively.
V78573	BuChE-IN-8		BuChE-IN-8 (compound 19c) is a butyrylcholinesterase (BuChE) inhibitor (antagonist) with IC50 of 559 nM.
V78510	BuChE-IN-9		BuChE-IN-9 (compound 22a) is a potent horse serum-derived BuChE (eqBuChE) inhibitor (antagonist) with IC50 of 173 nM.
V71655	Chikusetsusaponin Ib	59252-87-8	Chikusetsusaponin Ib has anti-Alzheimer's disease (AD) activity and is a potent AChE inhibitor.
V71653	Chlorpyrifos-d10	285138-81-0	Chlorpyrifos-d10 is the deuterated form of Chlorpyrifos.
V71622	Chlorpyrifos-oxon	5598-15-2	Chlorpyrifos-oxo, an bioactive metabolite of Chlorpyrifos, is a potent phosphorylating agent that effectively inhibits AChE.
V71632	Chlorpyrifos-oxon-d10	1794779-85-3	Chlorpyrifos-oxon-d10 is the deuterated form of Chlorpyrifos-oxon.
V77148	Choline Chloride-13C3 (Choline Chloride 13C3)		Choline Chloride-13C3 is a 13C (carbon 13)-labeled choline (chloride).
V71616	Choline-d4 chloride (choline d4 chloride (chloride))	285979-70-6	Choline-d4 (chloride) is the deuterated form of Choline chloride.
V71617	Choline-d9 chloride (choline d9 chloride (chloride))	61037-86-3	Choline-d9 (chloride) is the deuterated form of choline chloride.
V17505	Corynoline	18797-79-0	Corynoline is a reversible and noncompetitive inhibitor of acetylcholinesterase (AChE) with IC50 of 30.6 μM.
V71680	Cyanidin-3-O-galactoside chloride (cyanidin galactoside; Ideain chloride)	27661-36-5	Cyanidin-3-O-galactoside chloride (Ideain chloride) is one of the components found in hawthorn peel (EPHF), with a content of 179.4 mg/g.
V71633	Cyclopenin ((±)-Isocyclopenine)	19553-26-5	Cyclopenin ((±)-Isocyclopenine) is a racemic form.
V71660	Dehydrodicentrine	19843-03-9	Dehydrodicentrine is an aporphine alkaloid extracted from the roots of S. epigaea and has an inhibitory effect on acetylcholinesterase (AChE) with IC50 of 2.98 μM.
V71640	Dehydrodiscretamine chloride	78134-82-4	Dehydrodiscretamine chloride is a dual (bifunctional) inhibitor of AChE and BChE with IC50 of 17.8 and 118.8 μM respectively.
V71638	Dehydrogeizerin	16850-91-2	Dehydrogeizerin is an inhibitor (blocker/antagonist) of acetylcholinesterase with IC50 of 9.7 μM.
V29399	Dehydronuciferine	7630-74-2	Dehydronuciferine, extracted from the leaves of Nelumbo nucifera Gaertn, is an acetylcholinesterase (AChE) inhibitor (antagonist) with IC50 of 25 μg/mL.