The central nervous system contains a family of enzymes known as cholinesterase (ChE), which catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid. This reaction is required for cholinergic neurons to return to their resting state after activation. It is one of many crucial enzymes required for the healthy operation of human nervous systems.
There are two: butyrylcholinesterase (BChE, acylcholine acylhydrolase), also referred to as nonspecific cholinesterase or pseudocholinesterase, and acetylcholinesterase (AChE, acetylcholine hydrolase). While BChE is made in the liver and is mainly found in plasma, AChE is mainly found in the blood on the membranes of red blood cells, at neuromuscular junctions, and in neural synapses. The relative substrate preferences of the two types of cholinesterase are different: AChE hydrolyzes acetylcholine more quickly while BChE hydrolyzes butyrylcholine more quickly.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71627 | Depramine (GP 31406) | 303-54-8 | Depramine (GP 31406) is a pharmacologically active tricyclic antidepressant. |
|
V70686 | Desoxypeganine (Deoxypeganine; Deoxyvasicine) | 495-59-0 | Desoxypeganine (Deoxypeganine) is an alkaloid and an orally bioavailable cholinesterase (BChE and AChE) and selective MAO-A inhibitor (antagonist) with IC50s of 2, 17 and 2 μM, respectively. |
|
V71659 | Dihydro Donepezil (Dihydro E2020) | 120012-04-6 | Dihydro Donepezil (Dihydro E2020) is a metabolite of Donepezil. |
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V71643 | Donepezil-d4 hydrochloride (E2020-d4) | 1219798-88-5 | Donepezil-d4 ( HCl) is the deuterated form of Donepezil HCl. |
|
V71644 | Donepezil-d7 hydrochloride (E2020-d7) | 1261394-20-0 | Donepezil-d7 ( HCl) is the deuterated form of Donepezil. |
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V79221 | Dual AChE-MAO B-IN-1 | Dual AChE-MAO B-IN-1 (compound 15) is an orally bioavailable, CNS-penetrating, potent inhibitor of human AChE (IC50=550 nM) and MAO-B (IC50=8.2 nM) . | |
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V79222 | Dual AChE-MAO B-IN-3 | Dual AChE-MAO B-IN-3 (compound C10) is a potent dual AChE/MAO-B inhibitor (antagonist) with IC50s of 0.58 and 0.41 μM, respectively. | |
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V71688 | Ebeiedinone (dehydrobeidine base) | 25650-68-4 | Ebeiedinone is a Fritillary steroid alkaloid that can inhibit the bioactivity of human whole blood cholinesterase (ChE) at a concentration of 0.1 mM with an inhibition rate of 69.0%. |
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V71646 | Echimidine N-oxide | 41093-89-4 | Echimidine N-oxide is a pyrrolizidine alkaloid with acetylcholinesterase (AChE) inhibitory activity (IC50=0.347 mM). |
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V79244 | Edrophonium-d5 chloride (Edrophonium d5 (chloride)) | Edrophonium-d5 (chloride) is the deuterated form of Edrophonium chloride. | |
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V71699 | eeAChE-IN-1 | 2763366-27-2 | eeAChE-IN-1 is a strong eeAChE inhibitor (antagonist) with IC50 of 23 nM. |
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V71696 | eeAChE-IN-2 | 2763366-33-0 | eeAChE-IN-2 is a strong eeAChE inhibitor (antagonist) with IC50 of 2 nM. |
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V29628 | Epiberberine | 6873-09-2 | Epiberberine is a natural anticancer alkaloidisolated fromCoptis chinensiswith the potential for the treatment of diabetic disease. |
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V4737 | Epiberberine Chloride | 889665-86-5 | Epiberberine Chloride,an alkaloid, is a natural anticancer agent isolated fromCoptis chinensiswith the potential for the treatment of diabetic disease. |
|
V79389 | Fasciculin-I (FAS-I) | Fasciculin-I was extracted from mambas venom. | |
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V71672 | Fasciculin-II (Fas-2) | 95506-56-2 | Fasciculin-II (Fas-2) is a potential inhibitor of acetylcholinesterase (AChE). |
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V71642 | Feralolide | 149418-38-2 | Feralolide is a dihydroisocoumarin extracted from the methanolic extract of aloe vera resin. |
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V71673 | Fosthiazate (fosthiazate) | 98886-44-3 | Fosthiazate is a broad-spectrum nematicide that can inhibit the synthesis of acetylcholinesterase in a variety of plant-parasitic nematodes such as Meloidogyne spp. |
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V79489 | hAChE-IN-1 | hAChE-IN-1 (Compound 24) is a potent inhibitor of hAChE with IC50 of 1.09 μM. | |
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V79517 | hAChE-IN-2 | hAChE-IN-2 is a potent hAChE inhibitor (antagonist) with IC50 of 0.71 μM. |
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