The central nervous system contains a family of enzymes known as cholinesterase (ChE), which catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid. This reaction is required for cholinergic neurons to return to their resting state after activation. It is one of many crucial enzymes required for the healthy operation of human nervous systems.
There are two: butyrylcholinesterase (BChE, acylcholine acylhydrolase), also referred to as nonspecific cholinesterase or pseudocholinesterase, and acetylcholinesterase (AChE, acetylcholine hydrolase). While BChE is made in the liver and is mainly found in plasma, AChE is mainly found in the blood on the membranes of red blood cells, at neuromuscular junctions, and in neural synapses. The relative substrate preferences of the two types of cholinesterase are different: AChE hydrolyzes acetylcholine more quickly while BChE hydrolyzes butyrylcholine more quickly.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V30596 | Violanthin | 40581-17-7 | Violanthin is a naturally occuring flavanoid 8-c-glycoside acting as apotent acetylcholinesterase (AChE) inhibitor with IC50 of 79.80 μM. |
|
V71692 | Xanthohumol I | 688360-06-7 | Xanthohumol I is a chalcone, an analogue of Xanthohumol. |
|
V76342 | Y13g dihydrochloride | Y13g di-HCl is a potent inhibitor of AChE and IL-6. | |
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V71706 | Z164597606 | 1050587-57-9 | Z164597606 is a selective BChE inhibitor (IC50= 1.3 and 1.7 μM for eqBChE and hBChE, respectively). |
|
V71625 | Zanapezil free base (TAK-147 free base) | 142852-50-4 | Zanapezil (TAK-147) free base is a potent, reversible and selective inhibitor of acetylcholinesterase (AChE). |
|
V71678 | α-NETA | 115066-04-1 | α-NETA is a potent, noncompetitive inhibitor of choline acetyltransferase (ChA) with IC50 of 9 μM. |
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