The ion channel known as the calcium channel exhibits selective permeability to calcium ions. Although there are ligand-gated calcium channels as well, it is sometimes referred to as a voltage-dependent calcium channel. Even though the concentration of Na+ outside of cells is 70 times higher than that of Ca2+, voltage-gated calcium (CaV) channels catalyze a rapid, highly selective influx of Ca2+ into cells. A side effect of some calcium channel blockers is that they slow your heart rate, which helps to lower blood pressure, treat angina, and regulate irregular heartbeats.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V37608 | FK962 | 283167-06-6 | FK962 is an enhancer of somatostatin release and has cognitive enhancement effects. |
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V51180 | FPL-64176 | 120934-96-5 | FPL64176 is a potent, non-dihydropyridine L-type calcium channel agonist with EC50 of 16 nM. |
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V79521 | FS-2 | FS-2 is a potent and specific L-type CaV channel inhibitor. | |
|
V21464 | Gabapentin enacarbil (XP-13512) | 478296-72-9 | Gabapentin enacarbil (XP-13512) is a prodrug of gabapentin which is ananticonvulsant and analgesic drug. |
|
V71484 | Gabapentin-d4 (Gabapentin d4) | 1185039-20-6 | Gabapentin-d4 is the deuterium labelled form of Gabapentin. |
|
V57234 | Globotriaosylsphingosine (lyso-Gb3) | 126550-86-5 | Globotriaosylsphingosine (lyso-Gb3) suppresses the growth of fibroblasts, their differentiation into myofibroblasts and collagen expression. |
|
V79669 | GTx1-15 | GTx1-15 is an inhibitor (blocker/antagonist) of cystine knot (ICK) peptide that can inhibit voltage-dependent calcium channel Cav3.1 and voltage-dependent sodium channels Nav1.3 and Nav1.7. | |
|
V81758 | htK | wt hMLN is a trace protein that can inhibit the SR Ca2+ pump (SERCA). | |
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V71527 | Huwentoxin I (HWTX-I) | 769973-37-7 | Huwentoxin I (HWTX-I) is a bioactive peptide toxin that can inhibit voltage-gated sodium channels and N-type calcium channels. |
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V71510 | Huwentoxin XVI | 1600543-88-1 | Huwentoxin XVI, an analgesic from the bird spider Ornithoctonus huwena, is a highly reversible and selective mammalian N-type calcium channel (IC50 approximately 60 nM) antagonist. |
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V80329 | Huwentoxin XVI TFA | Huwentoxin XVI TFA, an analgesic from the bird spider Ornithoctonus huwena, is a highly reversible and selective mammalian N-type calcium channel (IC50 approximately 60 nM) antagonist. | |
|
V70140 | Hyperforin (Hyperforin) | 11079-53-1 | Hyperforin is a transient receptor canonical 6 (TRPC6) channel activator. |
|
V71519 | Imperatoroxin A | 172451-37-5 | Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, is an activator of Ca2+-releasing channels/ryanodine receptors (RyRs), which promotes Ca2+ influx into cells from the sarcoplasmic reticulum. |
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V71475 | JTV-519 hemifumarate (K201 hemifumarate) | 1435938-25-2 | JTV-519 hemifumarate (K201 hemifumarate) is a Ca2+-dependent sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) blocker. |
|
V80520 | Kurtoxin | Kurtoxin is a selective Cav3 (T-type) voltage-gated Ca2+ channel gating inhibitor (antagonist) with a Kd of 15 nM for Cav3.1 (α1G T-type) Ca2+ channels. | |
|
V76809 | L-Phenylalanine-15N,d8 ((S)-2-Amino-3-phenylpropionic acid-15N,d8) | L-Phenylalanine-15N,d8 is 15N (Nitrogen 15)-labelled and deuterated L-Phenylalanine. | |
|
V11739 | Lercanidipine | 100427-26-7 | Lercanidipine (REC-15-237, Lercadip, Lerdip, Zanidip)is a 3rd generation and lipophilic CCB (calcium channel blocker) of the dihydropyridine class and a medication used to treat high blood pressure, with long lasting antihypertensive action and reno-protective effect. |
|
V71494 | Lercanidipine-13C,d3 hydrochloride (Lercanidipine hydrochloride-13C,d3; Lercanidipine hydrochloride-13C,d3) | 1261397-71-0 | Lercanidipine-13C,d3 ( HCl) is the deuterated form of 13C (carbon 13)-labeled Lercanidipine HCl. |
|
V71507 | LOE 908 hydrochloride | 143482-60-4 | LOE 908 HCl is a non-selective cation channel (NSCC) inhibitor. |
|
V71533 | Maurocalcine | 269745-22-4 | Maurocalcine is a cell-permeable (penetrable) ryanodine receptor (RyR) channel type 1, 2 and 3 agonist. |
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