The ion channel known as the calcium channel exhibits selective permeability to calcium ions. Although there are ligand-gated calcium channels as well, it is sometimes referred to as a voltage-dependent calcium channel. Even though the concentration of Na+ outside of cells is 70 times higher than that of Ca2+, voltage-gated calcium (CaV) channels catalyze a rapid, highly selective influx of Ca2+ into cells. A side effect of some calcium channel blockers is that they slow your heart rate, which helps to lower blood pressure, treat angina, and regulate irregular heartbeats.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71515 | sFTX-3.3 | 141997-14-0 | sFTX-3.3 is a Ca2+ channel antagonist (inhibitor) with IC50 of approximately 0.24 mM and 0.70 mM for P-type and N-type Ca2+ channels, respectively. |
|
V71472 | SG-094 | 2922283-37-0 | SG-094 is a potent TPC2 inhibitor (antagonist) with anti-proliferation activity. |
|
V71476 | SNX-482 | 203460-30-4 | SNX-482, a peptidyl toxin from the spider Hysterocrates gigas, is a potent, high-affinity, selective and voltage-dependent R-type CaV2.3 channel blocker with IC50 of 30 nM. |
|
V71503 | T-Type calcium channel inhibitor 2 | 2771965-57-0 | T-Type calcium channel inhibitor 2 (compound 6g) is a potent T-type calcium channel inhibitor. |
|
V71511 | Taurolithocholic Acid-d5 sodium | 1265476-97-8 | Taurolithocholic Acid-d5 (sodium) is the deuterated form of Taurolithocholic acid sodium salt. |
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V71529 | TMB-8 | 53464-72-5 | TMB-8 is a novel Ca 2+ antagonist. |
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V71535 | TMDJ-035 | 2681302-83-8 | TMDJ-035 is a selective RyR2 inhibitor. |
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V71470 | TPC2-A1-N | 136186-07-7 | TPC2-A1-N is a potent Ca2+-permeable (penetrable) two-pore channel 2 (TPC2) agonist that acts by mimicking the physiological effects of NAADP. |
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V71534 | UK-59811 hydrochloride | 2250025-89-7 | UK-59811 HCl is a Br-dihydropyridine analogue and is a potent bacterial homotetrameric model voltage-gated Ca2+ (CaV) channel CaVAb inhibitor (antagonist) with IC50 of 194 nM. |
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V76358 | Verapamil-d3 hydrochloride ((±)-Verapamil-d3 (hydrochloride); CP-16533-1-d3 (hydrochloride)) | Verapamil-d3 ( HCl) is the deuterium labelled form of Verapamil HCl. | |
|
V2281 | VK-II-36 | 955371-66-1 | VK-II-36 is a carvedilol analog that can inhibit sarcoplasmic reticulum calcium release but does not block beta receptors. |
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V71531 | YS 035 hydrochloride | 89805-39-0 | YS 035 HCl is a Ca2+ antagonist of calcium ion cellular uptake and mitochondrial efflux. |
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V71474 | Ziconotide acetate (Ziconotide acetate; SNX-111 acetate) | 914454-03-8 | Ziconotide acetate (SNX-111 acetate) is a bioactive peptide that is a potent and specific antagonist blocker of N-type calcium channels. |
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V81772 | Ziconotide TFA (SNX-111 TFA) | Ziconotide TFA (SNX-111 TFA) is a bioactive peptide that is a potent and specific antagonist blocker of N-type calcium channels. | |
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V71542 | α2δligand 1 | 313653-15-5 | α2δ ligand 1 is from patent US20040186177, which is a ligand for the voltage-sensitive calcium channel α2δ-1. |
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V71496 | β-Cyfluthrin (beta-Cyfluthrin) | 1820573-27-0 | Beta-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and the active ingredient in many insecticide products used in agriculture to treat insect pests. |
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V81818 | γ-Glutamylserine TFA (γ-Glu-Ser TFA) | γ-Glutamylserine TFA (γ-Glu-Ser TFA) is a calcium receptor agonist/activator. | |
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V71498 | ω-Agatoxin IVA | 145017-83-0 | ω-Agatoxin IVA is a potent and specific P/Q-type Ca2+ (Cav2.1) channel blocker with IC50 of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. |
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V81827 | ω-Agatoxin IVA TFA | ω-Agatoxin IVA TFA is a potent and specific P/Q-type Ca2+ (Cav2.1) channel blocker with IC50 of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. | |
|
V71479 | ω-Agatoxin TK | 158484-42-5 | ω-AgatoxinTK, a peptidyl toxin in the venom of Agelenopsis aperta, is an effective and selective P/Q-type Ca2+ channel blocker. |
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