| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
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| Targets |
MC1R
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|---|---|
| ln Vitro |
ACTH.(1–17) Strong agonists of hMC1R include TFA. With a Ki value of 0.21±0.03 nM, the affinity of ACTH(1-17) for hMC1R is high, marginally higher than that of alpha-MSH at 0.13±0.005 nM[1]. Acth(1-17) stimulates growth hormone production in rat pituitary cultures even at micromolar doses [2], albeit not significantly.
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| ln Vivo |
Two hours after the daily dark span begins, nocturnal animals become active, and inhibition of DNA tagging is observed when ACTH (1-17) is delivered. Larger doses in particular were linked to a 24-hour reduction of DNA labeling when given during this circadian phase. The inhibitory impact was significantly reduced when the same amount was administered four hours earlier [3].
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| References |
[1]. Tsatmali M et al. ACTH1-17 is a more potent agonist at the human MC1 receptor than alpha-MSH. Cell Mol Biol (Noisy-le-grand). 1999 Nov;45(7):1029-34.
[2]. Ceda GP, et al. The effects of ACTH (1-17) on GH secretion in vitro. Horm Metab Res. 1987 Aug;19(8):361-3. [3]. Walker WV, et al. Effect of an adrenocorticotropin analogue, ACTH (1-17), on DNA synthesis in murine metaphyseal bone. Biochem Pharmacol. 1985 Apr 15;34(8):1191-6. |
| Molecular Formula |
C95H145N29O23S.C2HF3O2
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|---|---|
| Molecular Weight |
2207.43
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| Related CAS # |
ACTH (1-17);7266-47-9
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Solubility (In Vitro) |
H2O :~100 mg/mL (~45.30 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (45.30 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.4530 mL | 2.2651 mL | 4.5302 mL | |
| 5 mM | 0.0906 mL | 0.4530 mL | 0.9060 mL | |
| 10 mM | 0.0453 mL | 0.2265 mL | 0.4530 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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