| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
| ln Vitro |
ACTH (1-17) TFA is a potent agonist of hMC1R. ACTH (1-17) has a high affinity for hMC1R with a Ki value of 0.21 ± 0.03 nM, slightly higher than the Ki value of α-MSH (0.13 ± 0.005 nM) [1]. Even when using micromolar concentrations of the peptide in rat pituitary cultures, ACTH (1-17) induces only a slight and insignificant increase in growth hormone secretion [2].
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|---|---|
| ln Vivo |
DNA marker inhibition was observed when ACTH (1-17) was injected 2 hours after the start of the circadian rhythm when nocturnal animals become active. When injected during this circadian rhythm, especially at larger doses, DNA marker inhibition lasted for 24 hours. If the same dose of ACTH was injected 4 hours earlier, the duration of inhibition was much shorter[3].
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| References |
| Molecular Formula |
C95H145N29O23S.C2HF3O2
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|---|---|
| Molecular Weight |
2207.43
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| Related CAS # |
ACTH (1-17)
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| Sequence |
Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-ArgSYSMEHFRWGKPVGKKR
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| SequenceShortening |
SYSMEHFRWGKPVGKKR
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| Appearance |
White to off-white solid
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| Synonyms |
α1-17-ACTH TFA
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: 请将本产品存放在密封且受保护的环境中（例如氮气下），避免暴露在潮湿和光照下。 |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~100 mg/mL (~45.30 mM; with sonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (45.30 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), Clear solution; Need ultrasonic.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.4530 mL | 2.2651 mL | 4.5302 mL | |
| 5 mM | 0.0906 mL | 0.4530 mL | 0.9060 mL | |
| 10 mM | 0.0453 mL | 0.2265 mL | 0.4530 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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