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    WIKI4
    WIKI4

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1357
    CAS #: 838818-26-1Purity ≥98%

    Description: WIKI4 (WIKI 4; WIKI-4) is a novel and potent Tankyrase inhibitor with potential anticancer activity. It inhibits Tankyrase2 (TNKS2) in the Wnt/β-catenin signaling pathway with an IC50 of 15 nM. 

    References: PLoS One. 2012;7(12):e50457.

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    Molecular Weight (MW)521.59
    FormulaC29H23N5O3S 
    CAS No.838818-26-1
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 7 mg/mL (13.4 mM)  
    Water: <1 mg/mL
    Ethanol: <1 mg/mL 
    Other info

    Chemical Name: 2-(3-((4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

    InChi Key: RNUXIZKXJOGYQP-UHFFFAOYSA-N

    InChi Code: InChI=1S/C29H23N5O3S/c1-37-22-11-9-21(10-12-22)34-26(20-13-15-30-16-14-20)31-32-29(34)38-18-4-17-33-27(35)23-7-2-5-19-6-3-8-24(25(19)23)28(33)36/h2-3,5-16H,4,17-18H2,1H3

    SMILES Code: O=C(NC1=CC=CC=C1C(NC2=CC=C(CCN3CC4=C(C=C(OC)C(OC)=C4)CC3)C=C2)=O)C5=CC=C(OC)C(OC)=C5

    Synonyms

    WIKI4; WIKI 4; WIKI-4


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    In Vitro

    In vitro activity: WIKI4 inhibitsWnt/ß-catenin signaling in all tested cell lines, including A375, DLD1 colorectal cancer, NALM6 B, U2OS osteosarcoma and hESCs. WIKI4 increases the steady-state abundance of theWnt/ß-catenin inhibitory protein, AXIN1 by inhibiting tankyrase activity, and thus preventing the ubiquitylation and degradation of AXIN proteins.


    Kinase Assay: WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2, and leads to inhibition of Wnt/beta-catenin signaling. 


    Cell Assay: WIKI4 inhibits expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling in cancer cell lines as well as in human embryonic stem cells. 

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    References

    PLoS One. 2012;7(12):e50457.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    WIKI4

    WIKI4 inhibits the functional outcomes of Wnt/ß-catenin signaling. PLoS One. 2012;7(12):e50457.
     
     

    WIKI4

    WIKI4 increases the steady-state abundance of the Wnt/ß-catenin inhibitory protein, AXIN1. PLoS One. 2012;7(12):e50457.
     

    WIKI4

    WIKI4 prevents ubiquitylation of AXIN and inhibits the enzymatic activity of TNKS2. PLoS One. 2012;7(12):e50457.


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