Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB.These proteins perform as two-component transcription factors that control gene expression and have an impact on a variety of biological processes, such as innate and acquired immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis.The immune system's reaction to infection is significantly regulated by NF-B. In addition, the etiology of chronic inflammatory illnesses such inflammatory bowel disease, rheumatoid arthritis, and asthma is influenced by the activation of the NF-B pathway. Septic shock, autoimmune and inflammatory disorders, viral infections, and poor immunological development have all been connected to faulty NF-B regulation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V29937 | Sinomenine hydrochloride (Cucoline) | 6080-33-7 | Sinomenine HCl (Cucoline), the hydrochloride salt of Sinomenine, is a naturally occuringalkaloid isolated from the root of the plant Sinomenium acutum. |
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V14936 | SM-7368 | 380623-76-7 | SM-7368 is an NF-kB inhibitor that targets the downstream MAPK p38. |
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V0764 | Sodium 4-Aminosalicylate | 6018-19-5 | Sodium 4-Aminosalicylate,the sodium salt of aminosalicylic acid and an analog of PABA/para-aminobenzoic acid,is an antibiotic used to treat MDR-TB/multidrug-resistant tuberculosis via NF-κB inhibition and free radical scavenging. |
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V0767 | Sodium salicylate | 54-21-7 | Sodium salicylate (Magsalyl;Kerasalicyl; Kerosal), thesodium salt of salicylic acid and a metabolite of acetylsalicylic acid, is an inhibitor of NF-kB with potential anti-inflammatory activity. |
|
V82282 | Sphingosine-1-phosphate (S1P) | 26993-30-6 | Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6, and GPR12. |
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V5108 | Sulfasalazine (NSC 667219) | 599-79-1 | Sulfasalazine (NSC-667219) is an approved antiinflammatory drug used for the treatment of rheumatoid arthritis, inflammatory bowel disease such as including ulcerative colitis and Crohns disease. |
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V81517 | TAT-14 TFA | TAT-14 TFA is a 14-mer peptide that works as an Nrf2 activator. | |
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V30311 | Tectochrysin | 520-28-5 | Tectochrysin (Techtochrysin) is one of the major flavonoids of Alpinia oxyphylla. |
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V82291 | Terpendole I | 167612-17-1 | Terpendole I is a fungal indole diterpene and an ACAT inhibitor (IC50=145 µM). |
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V82257 | Thalidomide-O-amido-PEG2-C2-NH2 (Cereblon Ligand-Linker Conjugates 10; E3 Ligase Ligand-Linker Conjugates 24) | 1957235-74-3 | Thalidomide-O-amido-PEG2-C2-NH2 combines an E3 ligase ligand and a linker to study cancer as an immunomodulator. |
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V70236 | TML-6 | 1462868-88-7 | TML-6 is an orally bioavailable curcumin analogue that can inhibit the synthesis of β-amyloid precursor protein and β-amyloid (Aβ). |
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V82285 | Tonlamarsen sodium (ION-904 sodium) | 2589926-21-4 | Tonlamarsen sodium is an angiotensinogen synthesis reducing agent with anti-hypertensive (blood pressure lowering) activity. |
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V2079 | Triptolide (PG490) | 38748-32-2 | Triptolide (also known as NSC 163062), a diterpene triepoxide, is an immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. |
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V79860 | Triptolide-d3 (PG490-d3) | Triptolide-d3 is the deuterated form of Triptolide. | |
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V82297 | Uracil-15N2 (uracil-15N2) | 5522-55-4 | Uracil-15N2 is 15N (nitrogen 15) labelled Uracil. |
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V82299 | Uracil-d4 (uracil-d4) | 24897-55-0 | Uracil-d4 is the deuterium labelled form of Uracil. |
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V82268 | Varioxepine A | 1623451-72-8 | Varioxepine A is a 3H-oxepine-containing alkaloid found in the seaweed-derived endophytic fungus Paecilomyces variotii. |
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V69821 | Vitisin A ((+)-Vitisin A) | 142449-89-6 | Vitisin A has antioxidant, anticancer, antiapoptotic, neuro-protection, and anti-inflammatory effects. |
|
V11702 | Withaferin A | 5119-48-2 | Withaferin A, a steroidal lactone class of NFkB/IkB Inhibitor, is a natural product extracted from Acnistus arborescens,Withania somnifera (Indian Winter cherry or Ashwagandha in Sanskrit) and other members of Solanaceae family. |
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V81780 | Z-VRPR-FMK TFA (VRPR) | Z-VRPR-FMK (TFA) (VRPR) is a tetrapeptide and selective and irreversible inhibitor of mucosa-associated lymphoid tissue lymphoma translocator 1 (MALT1). |
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