| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V4487 | Edotecarin | 174402-32-5 | Edotecarin (formerly ED-749; J-107088; J 107088; PF 804950) is a novel and potent inhibitor oftopoisomerase Ithat can induces single-strand DNA cleavage withIC50of 50 nM. |
|
V5256 | Elenbecestat (E2609) | 1388149-39-0 | Elenbecestat (E-2609; E2609) is a novel, potent orally bioactive and BBB-penetrantBACE1 inhibitor which can reduce the plasma beta-amyloid levels after single dosing and has the potential for the treatment of Alzheimers disease (AD). |
|
V4492 | Fosdagrocorat | 1044535-58-1 | Fosdagrocorat (formerly known as PF-04171327) is a phosphate ester prodrug of PF-00251802 (dagrocorat), a selective high-affinity partial agonist of the glucocorticoid receptor, which is further metabolized to PF-04015475. |
|
V5296 | Furathiocarb | 65907-30-4 | Furathiocarb is a carbamate pesticide |
|
V4485 | Gosogliptin | 869490-23-3 | Gosogliptin (formerly also known as PF-734200 and PF-00734200) is a novel, potent and selective inhibitor ofdipeptidyl peptidase-IV(DPP-IV). |
|
V5310 | Lanraplenib (GS-9876) | 1800046-95-0 | Lanraplenib (also known as GS-9876; GS-SYK) is a highly selective and orally bioavailable Spleen Tyrosine Kinase (SYK) inhibitor with IC50of 9.5 nM). |
|
V5213 | Lesraurtinib (CEP701; KT5555) | 111358-88-4 | Lestaurtinib (CEP-701; KT-5555; SP-924) is a novel,orally bioavailable and potent multi-kinase inhibitor with anticancer and anti-inflammatory activity. |
|
V5289 | NE10790 (3-PEHPC) | 152831-36-2 | NE10790, an analog of risedronate, is a poor farnesyl pyrophosphate synthase inhibitor and a weak antiresorptive agent. |
|
V5331 | Ornoprostil (OU-1308) | 70667-26-4 | Ornoprostil (OU-1308),a methyl derivative of PGE1 developed in Japan, is a prostaglandin E1 analogue that acts as a mucosal protectant. |
|
V4458 | PF-00446687 | 862282-10-8 | PF-00446687 is a novel, potent,highly selective, brain penetrant small-molecule MC4R (melanocortin-4 receptor) agonist withEC50of 12 ± 1 nM. |
|
V4428 | PF-03709270 | 1000296-70-7 | PF-03709270 (also known as Sulopenem etzadroxil; PF 03709270) is a novel, potent and orally bioavailable ester prodrug of sulopenem, with broad-spectrum antibacterial activity against most gram-positive and gram-negative bacteria. |
|
V4480 | PF-06250112 | 1609465-89-5 | PF-06250112 is a novel, potent, highly selective, orally bioavailableBTKinhibitor with anIC50of 0.5 nM, shows inhibitory effect towardBMX nonreceptor tyrosine kinaseandTECwithIC50s of 0.9 nM and 1.2 nM, respectively. |
|
V5277 | PF-06263276 | 1421502-62-6 | PF-06263276 (PF6263276) is a novel, indazole-based, potent and selective pan-JAK inhibitor with anti-inflammatory and immunomodulatory effects. |
|
V4479 | PF-06795071 | 2075629-81-9 | PF-06795071 is a novel, potent, selective and covalentMAGL (Monoacylglycerol lipase)inhibitor with anIC50of 3 nM and with en excellent CNS exposure. |
|
V4429 | PF-06821497 | 1844849-11-1 | PF-06821497 (PF06821497) is a novel, potent, selective and orally bioactiveEnhancer of Zeste Homolog 2 (EZH2)inhibitor with potential anticancer effects. |
|
V4464 | PF-3893787 | 943057-12-3 | PF-3893787 (also known as Adriforant; ZPL-3893787; PF-3893787 and ZPL-389) is a novel and potent histamine H4 receptorantagonist with Kiof 2.4 nM and it is also a functional antagonist with Kiof 1.56 nM. |
|
V4444 | PF-4778574 | 1219633-99-4 | PF-4778574 is a novel and potent positive allosteric modulation (PAM) ofAMPAreceptor withEC50of 45 to 919 nM in differenct cells. |
|
V4449 | PF-592379 | 710655-15-5 | PF-592379 (PF592379) is a novel, potent and selective agonist ofdopamine D3receptoragonist (EC50 = 21 nM) with the potential for the treatment of male erectile dysfunction and female sexual dysfunction. |
|
V4424 | PF-750 | 959151-50-9 | PF 750 is a novel, potent, selective and covalent/irreversiblefatty acid amide hydrolase (FAAH)inhibitor, withIC50svarying from 16.2-595 nM. |
|
V5264 | Photo-lysine HCl | Photo-lysine HCl is a novel lysine-based photo-reactive amino acid, which captures proteins that bind lysine post-translational modifications. |
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