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    PF-3893787
    PF-3893787

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4464
    CAS #: 943057-12-3 (free)Purity ≥98%

    Description: PF-3893787 (also known as Adriforant; ZPL-3893787; PF-3893787 and ZPL-389) is a novel and potent histamine H4 receptor antagonist with Ki of 2.4 nM and it is also a functional antagonist with Ki of 1.56 nM. Adriforant shows an excellent in vitro profile that warrants their further investigation in relevant models of human disease. Histamine H4 receptor (H4R) has become a promising target for immuno-inflammatory diseases, such as allergic rhinitis, asthma or dermal allergies.

    References: Bioorg Med Chem Lett. 2011 Nov 1;21(21):6596-602.

    Related CAS: 2096455-90-0 (PF-3893787 hydrochloride)

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    PF-3893787

    Name: PF-3893787/Adriforant
    CAS#: 943057-12-3
    Chemical Formula: C13H22N6
    Exact Mass: 262.19059
    Molecular Weight: 262.36
    Elemental Analysis: C, 59.51; H, 8.45; N, 32.03
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: PF-3893787; PF3893787; PF 3893787; Adriforant; ZPL-3893787; ZPL3893787; ZPL 3893787; ZPL-389; ZPL 389; ZPL389; PF-03893787; PF03893787; PF 03893787;
    IUPAC/Chemical Name: (R)-N4-(cyclopropylmethyl)-6-(3-(methylamino)pyrrolidin-1-yl)pyrimidine-2,4-diamine
    InChi Key: ISBHYKVAFKTATD-SNVBAGLBSA-N
    InChi Code: InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1
    SMILES Code: NC1=NC(N2CC[[email protected]@H](NC)C2)=CC(NCC3CC3)=N1


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