Size | Price | |
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10mg | ||
25mg | ||
50mg |
Purity: ≥98%
PF-4778574 is a novel and potent positive allosteric modulation (PAM) of AMPA receptor with EC50 of 45 to 919 nM in differenct cells. Working memory impairments are a core aspect of schizophrenia, yet current medicines do not address such cognitive dysfunction. Positive modulation of AMPA receptors with LY451646 (0.1-1.0mg/kg, SC) and structurally distinct PF-4778574 (0.01mg/kg, SC) robustly ameliorates ketamine-induced working memory impairments without altering behavioral effects of acute ketamine we consider related to positive- and negative-like symptoms. These results support AMPA receptor potentiators as a potential adjunctive treatment for cognitive impairment associated with schizophrenia (CIAS).
References |
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Molecular Formula |
C19H22N2O3S2
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Molecular Weight |
390.51958
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CAS # |
1219633-99-4
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SMILES |
CC(S(=O)(N[C@@H]1[C@@H](C2=CC=C(C3=CC=C(C#N)S3)C=C2)COCC1)=O)C
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InChi Key |
FFAGHPLLBXWCSF-MSOLQXFVSA-N
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InChi Code |
InChI=1S/C19H22N2O3S2/c1-13(2)26(22,23)21-18-9-10-24-12-17(18)14-3-5-15(6-4-14)19-8-7-16(11-20)25-19/h3-8,13,17-18,21H,9-10,12H2,1-2H3/t17-,18+/m1/s1
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Chemical Name |
2-Propanesulfonamide, N-((3R,4S)-3-(4-(5-cyano-2-thienyl)phenyl)tetrahydro-2H-pyran-4-yl)-
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Synonyms |
PF-4778574; PF 4778574; PF4778574.
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.5607 mL | 12.8034 mL | 25.6069 mL | |
5 mM | 0.5121 mL | 2.5607 mL | 5.1214 mL | |
10 mM | 0.2561 mL | 1.2803 mL | 2.5607 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.