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    PF-4778574
    PF-4778574

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V4444
    CAS #: 1219633-99-4 Purity ≥98%

    Description: PF-4778574 is a novel and potent positive allosteric modulation (PAM) of AMPA receptor with EC50 of 45 to 919 nM in differenct cells. Working memory impairments are a core aspect of schizophrenia, yet current medicines do not address such cognitive dysfunction. Positive modulation of AMPA receptors with LY451646 (0.1-1.0mg/kg, SC) and structurally distinct PF-4778574 (0.01mg/kg, SC) robustly ameliorates ketamine-induced working memory impairments without altering behavioral effects of acute ketamine we consider related to positive- and negative-like symptoms. These results support AMPA receptor potentiators as a potential adjunctive treatment for cognitive impairment associated with schizophrenia (CIAS).

    References: Behav Brain Res. 2010 Sep 1;212(1):41-8.


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    PF-4778574

    Name: PF-4778574
    CAS#: 1219633-99-4
    Chemical Formula: C19H22N2O3S2
    Exact Mass: 390.1072
    Molecular Weight: 390.52
    Elemental Analysis: C, 58.44; H, 5.68; N, 7.17; O, 12.29; S, 16.42
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: PF-4778574; PF 4778574; PF4778574.
    IUPAC/Chemical Name: 2-Propanesulfonamide, N-((3R,4S)-3-(4-(5-cyano-2-thienyl)phenyl)tetrahydro-2H-pyran-4-yl)-
    InChi Key: FFAGHPLLBXWCSF-MSOLQXFVSA-N
    InChi Code: InChI=1S/C19H22N2O3S2/c1-13(2)26(22,23)21-18-9-10-24-12-17(18)14-3-5-15(6-4-14)19-8-7-16(11-20)25-19/h3-8,13,17-18,21H,9-10,12H2,1-2H3/t17-,18+/m1/s1
    SMILES Code: CC(S(=O)(N[[email protected]@H]1[[email protected]@H](C2=CC=C(C3=CC=C(C#N)S3)C=C2)COCC1)=O)C


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