One of the main downstream targets of the PtdIns(3,4,5)P3 signaling pathway is the serine/threonine protein kinase Akt/PKB (Protein Kinase B), which has antiapoptotic activity. It has a pleckstrin homology (PH) domain that binds PtdIns(3,4,5)P3 on the plasma membrane in a particular way. The amount of PtdIns(3,4,5)P3 on the plasma membrane, which is controlled by PI3K, directly affects Akt phosphorylation and activation.
There are three isoforms of Akt: PKB/Akt1, PKB/Akt2, and PKB/Akt3. The PH (pleckstrin homology) domain and the kinase domain of the Akt isoforms are separated by a 39-amino-acid hinge region. Numerous substrates involved in cell survival, growth, proliferation, metabolism, and protein synthesis are controlled by catalytically active Akt.
A key mediator of cell survival, Akt, is deactivated in a number of diseases that involve pathological cell death brought on by stress.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V84777 | Cucurbitacin C | 5988-76-1 | ||
V70208 | Dehydrovomifoliol | 39763-33-2 | Dehydrovomifoliol is a dual (bifunctional) inhibitor of AKT/mTOR. | |
V19575 | Esculetin | 305-01-1 | Esculetin is a naturally occuring β-catenin inhibitor found mainly in chicory and other plant sources with antioxidant, antiinflammatory, and antitumor activities. | |
V0157 | GSK-690693 | 937174-76-0 | GSK690693, an aminofurazan derivative, is a novel, potent andATP-competitivepan-Akt inhibitor targeting Akt1/2/3 with potential anticancer activity. | |
V3837 | GSK2110183 | 1047634-63-8 | GSK2110183, an analog ofAfuresertib, is a potent, orally bioavailable andATP-competitive Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. | |
V4633 | GSK2110183 HCl | 2070009-64-0 | GSK2110183 HCl, an analog ofAfuresertib, is a potent, orally bioavailable andATP-competitive Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. | |
V69830 | H-Ile-Lys-Val-Ala-Val-OH | 131167-89-0 | H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of lamin-1. | |
V69802 | Insulin Detemir | 169148-63-4 | Insulin Detemir is an artificial insulin that controls blood sugar levels. | |
V83971 | INY-05-040 | 2503018-29-7 | ||
V0158 | Ipatasertib (GDC0068; RG7440) | 1001264-89-6 | Ipatasertib (formerly also called GDC-0068; RG-7440) is a novel, potent, orally bioavailable, ATP-competitive and highly selective pan-Akt inhibitor targeting Akt1/2/3 with potential anticancer activity. | |
V33006 | Ipatasertib dihydrochloride (GDC-0068) | 1396257-94-5 | Ipatasertib dihydrochloride (formerly also called GDC-0068) is a novel, potent, orally bioavailable, ATP-competitive and highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM in cell-free assays, it showed 620-fold selectivity over PKA. | |
V85001 | Isomaltulose monohydrate | 58024-13-8 | ||
V84682 | JE-133 | 2579171-69-8 | ||
V33314 | K-80003 | 1292821-90-9 | K-80003 effectively inhibits tRXRα-dependent Akt activation and tumor cell growth. | |
V51338 | Kihadanin B | 73793-68-7 | citrus limonoidl inhibitor of Akt-FOXO1-PPARγ axis | |
V0166 | Miltefosine (Impavido; HePC) | 58066-85-6 | Miltefosine(Impavido; HePC), an alkyl-phosphocholine compound, is a potent,orally- and topically-bioactive,broad spectrum antimicrobial and anti-leishmanial medication that also haspotential antineoplastic activity. | |
V3318 | Miransertib HCl (ARQ 092; MK-7075) | 1313883-00-9 | Miransertib HCl (formerly known as ARQ-092; MK7075), the HCl salt ofMiransertib, is a novel, orally bioactive and selective allosteric inhibitor of AKT anticancer activity. | |
V0155 | MK-2206 2HCl | 1032350-13-2 | MK-2206 dihydrochloride (2HCl) is a novel, potent, orally bioavailable and highly selective allosteric inhibitor of the serine/threonine protein kinase Akt1/2/3 with potential anticancer activity. | |
V25651 | ML 9 HCl salt | 105637-50-1 | ML-9 HCl is a novel, potent and selective myosin light chain kinase (MLCK) inhibitor, also Akt kinase andand stromal interaction molecule 1 (STIM1). | |
V70204 | Monomethyl lithospermate (Lithospermic acid monomethyl ester) | 933054-33-2 | Monomethyl lithospermate activates the PI3K/AKT pathway and exerts a protective effect on nerve damage. |