Sirtuin (Sir2 proteins) are a group of proteins that have deacylase activity, such as deacetylase, desuccinylase, demalonylase, demyristoylase, and depalmitoylase. Sirtuins control crucial biological processes in eukaryotes, archaea, and bacteria. Sirtuins have been linked to a variety of cellular functions, including energy efficiency and alertness under low-calorie conditions as well as aging, transcription, apoptosis, inflammation, and stress resistance. Circadian clocks and mitochondrial biogenesis can both be regulated by sirtuins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V4054 | SRT1720 | 925434-55-5 | SRT1720 (formerly known as CAY10559) is a novel and selective SIRT1 activator with an EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. |
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V0428 | SRT1720 HCL (CAY-10559) | 1001645-58-4 | SRT1720 HCl (formerly known as CAY10559 HCl), the hydrochloride salt ofSRT1720, is a novel, potent and selective SIRT1(Sirtuin 1) activator with potential anticancer activity and isa promising new therapeutic agent for treating type 2 diabetes. |
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V0438 | SRT2104 (GSK-2245840) | 1093403-33-8 | SRT2104 (formerly GSK-2245840; SRT2104;GSK2245840;SRT-2104) is a novel, first-in-class, brain penetrant, and highly selective small molecule activator of SIRT1 (Sirtuin 1) with potential use forneurodegenerative diseases. |
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V2699 | SRT3025 HCL | 2070015-26-6 | SRT3025 is an orally bioactive small molecule activator of the SIRT1 enzyme. |
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