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    HA130
    HA130

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V3384
    CAS #: 1229652-21-4Purity ≥98%

    Description: HA130 is a novel, potent and selective inhibitor of autotaxin (ATX) with an IC50 of 28 nM. HA130 inhibits the enzymatic activity of ATX, and slows T cell migration across lymph node HEVs in vivo. Ex vivo, HA130 blunts the TEM-promoting activity of ATX, paralleling its in vivo effects. Autotaxin (ATX) is an ectoenzyme that catalyzes the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), a bioactive lipid and a close relative of sphingosine 1-phosphate. 

    References:  2013 Mar 1;190(5):2036-48;  2012 Oct 15;189(8):3914-24. 

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    HA130Name: HA130
    CAS#: 1229652-21-4
    Chemical Formula: C24H19BFNO5S
    Exact Mass: 463.1061
    Molecular Weight: 463.29
    Elemental Analysis: C, 62.22; H, 4.13; B, 2.33; F, 4.10; N, 3.02; O, 17.27; S, 6.92
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: HA130; HA-130; HA 130
    Chemical Name: (Z)-(3-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)phenyl)boronic acid
    InChi Key: VTNKMYWFWQTEHE-XKZIYDEJSA-N
    InChi Code: InChI=1S/C24H19BFNO5S/c26-20-8-4-17(5-9-20)14-27-23(28)22(33-24(27)29)13-16-6-10-21(11-7-16)32-15-18-2-1-3-19(12-18)25(30)31/h1-13,30-31H,14-15H2/b22-13-
    SMILES Code: OB(C1=CC=CC(COC2=CC=C(/C=C(SC(N3CC4=CC=C(F)C=C4)=O)/C3=O)C=C2)=C1)O


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    HA130


    HA130 impedes T cell entry into lymph nodes.   2012 Oct 15;189(8):3914-24.
     HA130


    Binding of ATX to T cells.  2012 Oct 15;189(8):3914-24.

     HA130


    ATX induces motility of na.  2012 Oct 15;189(8):3914-24.


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