Phosphatases are enzymes that strip a protein of its phosphate group. PTPs (protein tyrosine phosphatases) are a large family of cytoplasmic and transmembrane enzymes. PTPs are crucial in maintaining the integrity of cell-cell and cell-matrix contacts as well as controlling the proliferative activity of cells. PTP1B, a non-receptor PTP, is frequently found in the endoplasmic reticulum and in vesicles that are close to the plasma membrane.PTP1B has been a popular therapeutic target for the management of type 2 diabetes mellitus and obesity due to its important role as a negative regulator of leptin receptor pathways. Animal cell cytoplasm contains four major serine/threonine-specific protein phosphatase catalytic subunits. While PP2C seems to be different from the other two, PP1, PP2A, and PP2B, all three of these enzymes are members of the same gene family. A diverse group of enzymes known as alkaline phosphatases is found in abundance in mammalian cells. Following the general equation, acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V31026 | Silydianin | 29782-68-1 | Silydianin is the active component of milk thistle and has anti-collagenase and anti-elastase activity. |
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V32196 | SMAP-2 | 1809068-70-9 | SMAP-2 (DT-1154;SMAP 2; DT1154;SMAP2;DT 1154) is a novel, potent and orally bioavailable phosphatase 2A (PP2A) activator with potential anticancer activity. |
|
V0182 | Sodium orthovanadate | 13721-39-6 | Sodium orthovanadate, an inorganic compound with chemical formula ofNa3VO4, is a potent inhibitor for several enzymes such as protein tyrosine phosphatases (PTPs), alkaline phosphatase (ALP), and ATPase. |
|
V73331 | Sophoraisoflavone A (Allolicoisoflavone B) | 117204-81-6 | Sophoraisoflavone A (Allolicoisoflavone B) is a naturally occurring compound extracted from Glycyrrhiza inflate. |
|
V73308 | SPAA-52 | 2837000-75-4 | SPAA-52 is an orally bioactive, competitive and reversible low molecular weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50=4 nM, Ki=1.2 nM). |
|
V81448 | Stevisalioside A | Stevisalioside A (Compound 2) can be extracted from stevia root. | |
|
V81449 | Stevisaliosides D | Stevisaliosides D (Compound 5) can be extracted from stevia root. | |
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V4335 | SURAMIN SODIUM | 129-46-4 | Suramin sodium salt, a polysulfonated naphthylurea analog, is a novel and potentDNA topoisomerase IIinhibitor with anIC50of 5 μM. |
|
V3607 | Tacrolimus Monohydrate | 109581-93-3 | Tacrolimus (formerly also known as FK-506), amacrocyclic lactone isolated from the culture broth of a strain of Streptomyces tsukubaensis, is an immunosuppressive agent used mainly after allogeneic organ transplant to reduce the activity of the patients immune system and to lower the risk of organ rejection. |
|
V3399 | TCS 401 | 243966-09-8 | TCS-401 HCI is a novel, potent and selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B)with Ki of 0.29 µM. |
|
V73309 | Tegeprotafib (PTPN2/1-IN-1) | 2407610-46-0 | Tegeprotafib (PTPN2/1-IN-1) is an orally bioactive PTPN1 and PTPN2 inhibitor (antagonist) with IC50s of 4.4 nM and 1-10 nM for PTPN2 and PTP1B, respectively. |
|
V73299 | TRC-766 | 1810734-44-1 | TRC-766 is a negative control (NC) for RTC-5 (TRC-382). |
|
V69424 | Tyrphostin 8 | 3785-90-8 | Tyrphostin 8 is a tyrosine kinase that can inhibit EGFR kinase with IC50 of 560 μM. |
|
V73305 | Uralenol | 139163-15-8 | Uralenol is a natural PTP1B inhibitor from Broussonetia papyrifera (IC50=21.5 μM). |
|
V73322 | Uralsaponin D | 1262489-44-0 | Uralsaponin D is a saponin extracted from Glycyrrhiza uralensis. |
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