Phosphatases are enzymes that strip a protein of its phosphate group. PTPs (protein tyrosine phosphatases) are a large family of cytoplasmic and transmembrane enzymes. PTPs are crucial in maintaining the integrity of cell-cell and cell-matrix contacts as well as controlling the proliferative activity of cells. PTP1B, a non-receptor PTP, is frequently found in the endoplasmic reticulum and in vesicles that are close to the plasma membrane.PTP1B has been a popular therapeutic target for the management of type 2 diabetes mellitus and obesity due to its important role as a negative regulator of leptin receptor pathways. Animal cell cytoplasm contains four major serine/threonine-specific protein phosphatase catalytic subunits. While PP2C seems to be different from the other two, PP1, PP2A, and PP2B, all three of these enzymes are members of the same gene family. A diverse group of enzymes known as alkaline phosphatases is found in abundance in mammalian cells. Following the general equation, acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V51322 | AQX-435 | 1619983-52-6 | AQX-435 is a potent activator of SHIP1 (SH2 domain-containing inositol-5′-phosphatase 1). |
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V77241 | ARL67156 trisodium hydrate (FPL 67156 trisodium hydrate) | ARL67156 (FPL 67156) trisodium hydrate is an ecto-ATPase inhibitor. | |
|
V2933 | BAMB-4(ITPKA-IN-C14) | 891025-25-5 | BAMB-4 (formerly known as ITPKA-IN-C14) is a novel and highlypotent membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA) with IC50 of 37 uM in ADP-Glo Assay. |
|
V13001 | BN-82002 | 396073-89-5 | BN-82002, formerly known as CDC25 Phosphatase Inhibitor I, is a cell-permeable ortho-hydroxybenzylamino compound that exhibits anti-tumor properties. |
|
V73287 | BN82002 hydrochloride | 1049740-43-3 | BN82002 HCl is a specific and irreversible pan-inhibitor of the CDC25 phosphatase family. |
|
V73337 | Caffeoyltryptophan | 109163-69-1 | Caffeoyltryptophan is a competitive PTP1B inhibitor (antagonist) with IC50 of 16.99 μM. |
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V73296 | Calcineurin autoinhibitory peptide | 148067-21-4 | Calcineurin autoinhibitory peptide is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin) with IC50 of approximately 10 μM. |
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V78607 | Calcineurin autoinhibitory peptide TFA | Calcineurin autoinhibitory peptide TFA is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin) with IC50 of approximately 10 μM. | |
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V73310 | Calcium glycerophosphate | 27214-00-2 | Calcium glycerophosphate is an inhibitor (blocker/antagonist) of intestinal alkaline phosphatase F3. |
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V70660 | Cassiaside B2 | 218155-40-9 | Cassiaside B2 is an inhibitor (blocker/antagonist) of protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A). |
|
V1938 | CCT007093 | 176957-55-4 | CCT007093, a thienylidene cyclopentanone, is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM. |
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V73294 | CDC25B-IN-1 | 2374831-10-2 | CDC25B-IN-1 (compound 4a) is a potent inhibitor of cell division cycle 25B (CDC25B) phosphatase with a Ki of 8.5 μM. |
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V73323 | CDC25B-IN-2 | 134271-74-2 | CDC25B-IN-2 is a potent inhibitor of cdc25B. |
|
V73345 | Chrysophanol triglucoside (Chrysophanol-1-O-β-triglucoside) | 120181-07-9 | Chrysophanol triglucoside is an anthraquinone compound extracted from Cassia seed and inhibits protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase with IC50s of 80.17 and 197.06 µM respectively. |
|
V73347 | cis-Ferulic acid 4-O-β-D-glucopyranoside | 94942-20-8 | cis-Ferulic acid 4-O-β-D-glucopyranoside (compound 7) is a phenolic glycoside extracted from Siberian white thorn. |
|
V2830 | CPDA | 1415834-63-7 | CPDA [N-[4-(4-chlorobenzyloxy)pyridin-2-yl]-2-(2,6-difluorophenyl)- acetamide] is a novel potent inhibitor of SHIP2 [SH2-containing 5-inositol phosphatase 2] that can effectively ameliorate insulin resistance in 3T3-L1 adipocytes. |
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V73289 | CPT-157633 | 888213-72-7 | CPT-157633 is a difluorophosphonomethylphenylalanine analogue and a PTP1B inhibitor. |
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V73354 | Cryptosporioptide A | 1647101-05-0 | Cryptosporioptide A (Compound 3) is a chromoprotein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. |
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V73313 | Cyanidin 3-arabinoside | 27214-72-8 | Cyanidin 3-arabinoside is a selective, reversible protein tyrosine phosphatase 1B (PTP1B) inhibitor (antagonist) with IC50 8.91 μM. |
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V73329 | Cyclosporin A-Derivative 3 | 121584-34-7 | Cyclosporin A-analogue 3 is an analogue of Cyclosporin A with calcineurin inhibitory activity. |
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