Phosphatase

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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Phosphatase

Phosphatases are enzymes that strip a protein of its phosphate group. PTPs (protein tyrosine phosphatases) are a large family of cytoplasmic and transmembrane enzymes. PTPs are crucial in maintaining the integrity of cell-cell and cell-matrix contacts as well as controlling the proliferative activity of cells. PTP1B, a non-receptor PTP, is frequently found in the endoplasmic reticulum and in vesicles that are close to the plasma membrane.PTP1B has been a popular therapeutic target for the management of type 2 diabetes mellitus and obesity due to its important role as a negative regulator of leptin receptor pathways. Animal cell cytoplasm contains four major serine/threonine-specific protein phosphatase catalytic subunits. While PP2C seems to be different from the other two, PP1, PP2A, and PP2B, all three of these enzymes are members of the same gene family. A diverse group of enzymes known as alkaline phosphatases is found in abundance in mammalian cells. Following the general equation, acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters.

Phosphatase related products

Cat No.	Product Name	CAS No.	Product Description
V73335	PTP1B-IN-19	2848581-83-7	PTP1B-IN-19 (Compound 43) is a potential and selective benzimidazole analogue as a protein tyrosine phosphatase 1B (PTP1B) inhibitor (antagonist) with Ki of 23.3 μM.
V78763	PTP1B-IN-20		PTP1B-IN-20 is a selective inhibitor (IC50=1.05 μM) of protein tyrosine phosphatase 1B (PTP1B), with inhibitory potency exceeding that of the highly homologous T cell protein tyrosine phosphatase (TCPTP; IC50=78.0 μM) , PTP1B is an important target for inhibiting type 2 diabetes.
V79520	PTP1B-IN-21		PTP1B-IN-21 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) (IC50=1.56 μM), with inhibitory potency exceeding that of the highly homologous T cell protein tyrosine phosphatase (TCPTP; IC50>100 μM) , PTP1B is an important target for inhibiting type 2 diabetes.
V73334	PTP1B-IN-22	86109-60-6	PTP1B-IN-22, a ZINC02765569 analogue, is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B).
V73292	PTP1B-IN-3 diammonium	2702673-78-5	PTP1B-IN-3 diammonium is a potent and specific PTP1B inhibitor (antagonist) with IC50s of 120 nM for both PTP1B and TCPTP.
V79459	PTP1B/AKR1B1-IN-1		PTP1B/AKR1B1-IN-1 is a dual (bifunctional) inhibitor of protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1) with IC50 of 0.06 μM and 4.3 μM, respectively.
V79225	PTP1B/AKR1B1-IN-2		PTP1B/AKR1B1-IN-2 (Compound 7f) is a dual PTP1B/AKR1B1 inhibitor (IC50s: 3.2 and 2.1 μM, Kis: 4.0 and 0.9μM).
V73281	PTPN2/1-IN-2	2407611-02-1	PTPN2/1-IN-2 is a PTPN2/1 antagonist that may be utilized in a variety of tumor studies.
V73283	PTPN22-IN-1	2580935-57-3	PTPN22-IN-1 is a potent inhibitor of PTPN22 (IC50=1.4 µM; Ki=0.50 µM).
V81253	PTPσ Inhibitor, ISP		PTPσ Inhibitor, ISP can bind to recombinant human PTP and inhibit PTPσ signaling.
V81256	PVD-06		PVD-06 is a selective PTPN2 degrader (PTPN2/PTP1B selectivity index >60-fold), inducing PTPN2 degradation in a ubiquitination- and proteasome-dependent manner.
V31912	Raphin1	2022961-17-5	Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B).
V31468	Raphin1 acetate	2242616-04-0	Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B).
V69761	RMC-3943	1801764-60-2	RMC-3943 is an allosteric SHP2 inhibitor (IC50 for full-length inhibition is 2.19 nM).
V13995	Rosiptor	782487-28-9	Rosiptor (AQX-1125; AQX1125; AQX 1125) is an orally bioavailable and selective activator of the phosphatase SHIP1 (SH2 domain-containing inositol-5′-phosphatase 1) with potential anti-inflammatory activities.
V1947	Sal003	1164470-53-4	Sal003 is a potent, selective and cell-permeable eIF-2α phosphatase inhibitor.
V69153	SC-43	1400989-25-4	SC-43, an analogue of Sorafenib, is a potent orally bioactive SHP-1 (PTPN6) agonist.
V69740	SHP099 monohydrochloride	2200214-93-1	SHP099 HCl is a potent, selective, orally bioactive SHP2 inhibitor (antagonist) with IC50 of 70 nM.
V69754	SHP2 inhibitor LY6 (LY6)	2296718-09-5	SHP2 inhibitor LY6 (LY6) is a potent and specific SHP2 inhibitor (antagonist) with IC50 of 9.8 µM.
V69760	SHP2/CDK4-IN-1	2924036-87-1	SHP2/CDK4-IN-1 (compound 10) is an orally bioavailable dual (bifunctional) inhibitor of SHP2 and CDK4 with IC50 of 4.3 and 18.2 nM, respectively.