Phosphatase

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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Phosphatase

Phosphatases are enzymes that strip a protein of its phosphate group. PTPs (protein tyrosine phosphatases) are a large family of cytoplasmic and transmembrane enzymes. PTPs are crucial in maintaining the integrity of cell-cell and cell-matrix contacts as well as controlling the proliferative activity of cells. PTP1B, a non-receptor PTP, is frequently found in the endoplasmic reticulum and in vesicles that are close to the plasma membrane.PTP1B has been a popular therapeutic target for the management of type 2 diabetes mellitus and obesity due to its important role as a negative regulator of leptin receptor pathways. Animal cell cytoplasm contains four major serine/threonine-specific protein phosphatase catalytic subunits. While PP2C seems to be different from the other two, PP1, PP2A, and PP2B, all three of these enzymes are members of the same gene family. A diverse group of enzymes known as alkaline phosphatases is found in abundance in mammalian cells. Following the general equation, acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters.

Phosphatase related products

Cat No.	Product Name	CAS No.	Product Description
V73328	NTPDase-IN-2	2883147-47-3	NTPDase-IN-2 (Compound 5g) is a selective NTPDase inhibitor (antagonist) with IC50s of 0.04 and 2.27 µM for h-NTPDase-2/-8, respectively.
V73314	NTPDase-IN-3	2883147-45-1	NTPDase-IN-3 (Compound 5e) is an NTPDase inhibitor (antagonist) with IC50s of 0.38 μM (NTPDase3), 0.05 μM (NTPDase8), 0.21 μM (NTPDase1), and 1.07 μM (NTPDase2).
V73300	PFKFB3-IN-2	794552-84-4	PFKFB3-IN-2 is a fructose-6-phosphate-2kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) inhibitor.
V73291	PGAM1-IN-1	2438637-65-9	PGAM1-IN-1 is a potent inhibitor of phosphoglycerate mutase 1 (PGAM1) with IC50 of 6.4 μM.
V73295	PGAM1-IN-2	2438637-66-0	PGAM1-IN-2 is a potent inhibitor of phosphoglycerate mutase 1 (PGAM1) with IC50 of 2.1 μM.
V57066	Phosphatase Binder-1	2456385-41-2	Phosphatase Binder-1 (comppund i-196) provides a bifunctional compound that effectively dephosphorylates certain phosphate-activated target proteins.
V1983	Pimecrolimus (ASM 981)	137071-32-0	Pimecrolimus (formerly known as ASM-981; SDZ-ASM981) is an ascomycin analog which acts asan immunomodulating agent and is used in the treatment of atopic dermatitis.
V73340	PLAP-IN-1	2857113-78-9	PLAP-IN-1 is a potent (IC50 = 32 nM) and selective PLAP inhibitor (antagonist) with no significant inhibitory effect on tissue non-specific alkaline phosphatase (TNAP) activity.
V73324	PP5-IN-1	1022417-69-1	PP5-IN-1 (Compound P053) is a competitive serine/threonine protein phosphatase-5 (PP5) inhibitor that binds to its catalytic domain and causes apoptosis in renal cancer cells.
V73306	PROTAC PTPN2 degrader-1	2655638-07-4	PROTAC PTPN2 degrader-1 (example compound 77) is a potent PTPN2 degrader.
V73316	PROTAC PTPN2 degrader-2	2912307-38-9	PROTAC PTPN2 degrader-2 (example 187B) is a potent PTPN2 degrader with potential for studying cancer or metabolic diseases.
V73346	PROTAC PTPN2 degrader-2 TFA	2912307-39-0	PROTAC PTPN2 degrader-2 (example 187B) TFA is a potent PTPN2 degrader with potential for studying cancer or metabolic diseases.
V69751	PTP Inhibitor IV	329317-98-8	PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity, 50 at 5.21 μM.
V2859	PTP1B-IN-1	612530-44-6	PTP1B-IN-1 is a potent and new class of inhibitor of protein tyrosine phosphatase-1B (PTP1B) with IC50 of 1.6 mM; Itincorporates the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template that was identified throughstructure-based design.
V73341	PTP1B-IN-13	650621-20-8	PTP1B-IN-13 is a selective PTP1B inhibitor that targets the allosteric site with IC50 of 1.59 μM.
V73332	PTP1B-IN-14	724451-35-8	PTP1B-IN-14 is a selective PTP1B inhibitor (IC50 = 0.72 μM) that targets allosteric sites.
V73297	PTP1B-IN-15	765317-71-3	PTP1B-IN-15 is a potent and specific inhibitor of protein tyrosine phosphatase 1B (PTP1B).
V73315	PTP1B-IN-16	2848581-86-0	PTP1B-IN-16 (Compound 46) is a potential and selective benzimidazole analogue as a protein tyrosine phosphatase 1B (PTP1B) inhibitor (antagonist) with Ki of 12.6 μM.
V73325	PTP1B-IN-17	2848581-85-9	PTP1B-IN-17 (Compound 45) is a potential and selective benzimidazole analogue as a protein tyrosine phosphatase 1B (PTP1B) inhibitor (antagonist) with Ki of 30.2 μM.
V73317	PTP1B-IN-18	2848581-84-8	PTP1B-IN-18 is an orally bioactive, fully mixed protein tyrosine phosphatase 1B (PTP1B) inhibitor (antagonist) with a Ki of 35.2 μM.