MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases.The metzincin superfamily of proteases, to which the MMPs belong, is a larger group of enzymes. MMPs can process a variety of bioactive molecules in addition to breaking down various extracellular matrix proteins. They have been linked to the inactivation of chemokines and cytokines as well as the cleavage of cell surface receptors and the release of apoptotic ligands.Additionally, it is believed that MMPs have a significant impact on the proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense of cells. It is believed that MMP-2 and MMP-9 are crucial for metastasis. MMP-1 is regarded as being significant in osteoarthritis and rheumatoid arthritis. Recent research indicates that MMPs are actively involved in the pathogenesis of aortic aneurysms. The structural proteins of the aortic wall are degraded by excess MMPs. Acute and chronic cardiovascular diseases both exhibit dysregulation of the balance between MMPs and TIMPs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V20627 | Epigallocatechin (EGC) | 970-74-1 | Epigallocatechin (also known as EGC; Epigallocatechin; L-Epigallocatechin)is a naturally occurringpolyphenol and flavonoidextractied from green tea, which shows multiple bioactivity. |
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V73237 | FFAGLDD | 2703745-70-2 | FFAGLDD is an MMP9-selective cleavage peptide for cytosolic delivery of doxorubicin (DOX) and achieves temporally and spatially controlled slow drug delivery and release. |
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V79409 | FFAGLDD TFA | FFAGLDD TFA is an MMP9-selective cleavage peptide for cytosolic delivery of doxorubicin (DOX) and achieves temporally and spatially controlled slow drug delivery and release. | |
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V77004 | FN-439 TFA | FN-439 TFA is a selective collagenase-1 inhibitor. | |
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V2835 | FT 011 | 1001288-58-9 | FT011 is a novel potent anti-inflammatory and anti-fibrotic agent that has been reported to attenuate organ damage in diabetic rats with cardiomyopathy and nephropathy. |
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V4081 | GI254023X | 260264-93-5 | GI254023X (also known as GI4023 and SRI028594) is a novel and potent inhibitor of MMP9 (Matrix Metallopeptidase 9)andADAM10 (A Disintegrin and Metalloproteinase 10) withIC50s of 2.5 and 5.3 nM, respectively. |
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V2172 | GW280264X | 866924-39-2 | GW280264X is an ADAM10/TACE (ADAM17) metalloproteinase inhibitor. |
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V33743 | Histatin 5 | 115966-68-2 | Histatin 5 is a novel and potent bioactive peptide compound that inhibits theactivity of MMP-2 and MMP-9 (host matrix metalloproteinases) with IC50s of 0.57 and 0.25 μM, respectively. |
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V76931 | Histatin 5 TFA (Histatin 5 Trifluoroacetate) | Histatin 5 TFA inhibits host matrix metalloproteinases MMP-2 and MMP-9 activities with IC50s of 0.57 and 0.25 μM, respectively. | |
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V4106 | Incyclinide | 15866-90-7 | Incyclinide (formerly known as CMT-3 and COL-3; 6-demethyl, 6-deoxy, 4-dedimethylamino TC; a chemically modified tetracycline) is a matrix metalloproteinase (MMP) inhibitor, it acts by inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. |
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V73261 | Isozedoarondiol | 108887-68-9 | Isozedoarondiol is extracted from the rhizome of Turmeric. |
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V31028 | Luteolin 7-O-glucuronide | 29741-10-4 | Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively. |
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V73252 | Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 | 158584-08-8 | Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 is a biologically active peptide. |
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V73219 | Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 | 720710-69-0 | Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide and a quenched MMP peptide substrate that may be utilized to quantify MMP enzymatic activity in real time . |
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V77797 | Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 | Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is a biologically active peptide. | |
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V73224 | MMP Inhibitor II | 203915-59-7 | MMP Inhibitor II (compound 4e) is a potent, reversible pan-MMP inhibitor (antagonist) with IC50s of 24 nM, 18.4 nM, 30 nM and MMP-9 for MMP-1, MMP-3, MMP-7 and MMP-9 respectively. |
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V80514 | MMP-1-IN-1 | MMP-1-IN-1 (Compound 6) is a potent MMP-1 inhibitor (antagonist) with IC50 of 0.034 μM. | |
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V73255 | MMP-13 Substrate | 1872435-02-3 | MMP-13 Substrate is a substrate for MMP-13. |
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V73238 | MMP-13-IN-1 | 2925249-49-4 | MMP-13-IN-1 is a potent and specific MMP-13 inhibitor (antagonist) with IC50 of 16 nM. |
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V73228 | MMP-2 Inhibitor I | 10335-69-0 | MMP-2 Inhibitor I (OA-Hy) is a potent MMP-2 inhibitor (antagonist) with Ki of 1.7 μM. |
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