MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases.The metzincin superfamily of proteases, to which the MMPs belong, is a larger group of enzymes. MMPs can process a variety of bioactive molecules in addition to breaking down various extracellular matrix proteins. They have been linked to the inactivation of chemokines and cytokines as well as the cleavage of cell surface receptors and the release of apoptotic ligands.Additionally, it is believed that MMPs have a significant impact on the proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense of cells. It is believed that MMP-2 and MMP-9 are crucial for metastasis. MMP-1 is regarded as being significant in osteoarthritis and rheumatoid arthritis. Recent research indicates that MMPs are actively involved in the pathogenesis of aortic aneurysms. The structural proteins of the aortic wall are degraded by excess MMPs. Acute and chronic cardiovascular diseases both exhibit dysregulation of the balance between MMPs and TIMPs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V32859 | S-methyl-KE-298 | 143584-75-2 | S-methyl-KE-298 is an active metabolite of KE-298, which is aninhibitor of matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells. |
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V73240 | TAPI-1 | 163847-77-6 | TAPI-1 is a TACE (ADAM17) inhibitor that prevents the shedding of multiple cell surface proteins. |
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V73251 | TNO211 | 193475-71-7 | TNO211 is a biologically active peptide. |
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V83233 | TP-0628103 | 2865102-08-3 | TP0628103 is a novel and selective MMP-7 inhibitor with IC50 of 0.17 nM. Anticancer activity. |
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V73232 | TP0556351 | 2787582-17-4 | TP0556351 is a potent and specific matrix metalloproteinase 2 (MMP2) inhibitor (antagonist) with IC50 of 0.2 nM. |
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V73231 | TP0597850 | 2642181-22-2 | TP0597850 is a selective inhibitor of MMP2 (IC50=0.22 nM). |
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V73253 | Trifloroside | 53823-10-2 | Trifloroside is an iridoid glycoside with antioxidant properties. |
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V73247 | VPLSLYSG | 425632-67-3 | VPLSLYSG is an octapeptide degraded by matrix metalloproteinase-9 (MMP-9), MMP-1, and MMP-2. |
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V73241 | Xanthopurpurin (Purpuroxanthin) | 518-83-2 | Xanthopurpurin is an anthraquinone glycoside extracted from the rhizome of Rubia akane. |
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V73223 | XL-784 free base | 1356992-21-6 | XL-784 free base is a selective inhibitor of MMP. |
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V69829 | β-Neo-Endorphin | 77739-21-0 | β-Neo-Endorphin is an endogenous opioid peptide. |
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V83271 | Collagenase, Type I | 9001-12-1 | Collagenase, Type I (EC 3.4.24.3) is one of the microbially derived matrix metalloproteinases (MMPs) and zinc peptidases. |
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V83272 | Collagenase, Type II | 9001-12-1 | Collagenase, Type II is one of the microbially derived matrix metalloproteinases (MMPs) and zinc peptidases. |
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V83273 | Collagenase, Type III | 9001-12-1 | Collagenase, Type III is one of the microbially derived matrix metalloproteinases (MMPs) and zinc peptidases. |
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V83274 | Collagenase, Type IV (Collagenase IV, Clostridium histolytica) | 9001-12-1 | Collagenase, Type IV (Collagenase IV, Clostridium histolytica) is one of the microbially derived matrix metalloproteinases (MMPs) and zinc peptidases. |
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V83275 | Collagenase, Type V | 9001-12-1 | Collagenase, Type V is one of the microbially derived matrix metalloproteinases (MMPs) and zinc peptidases. |
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