MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases.The metzincin superfamily of proteases, to which the MMPs belong, is a larger group of enzymes. MMPs can process a variety of bioactive molecules in addition to breaking down various extracellular matrix proteins. They have been linked to the inactivation of chemokines and cytokines as well as the cleavage of cell surface receptors and the release of apoptotic ligands.Additionally, it is believed that MMPs have a significant impact on the proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense of cells. It is believed that MMP-2 and MMP-9 are crucial for metastasis. MMP-1 is regarded as being significant in osteoarthritis and rheumatoid arthritis. Recent research indicates that MMPs are actively involved in the pathogenesis of aortic aneurysms. The structural proteins of the aortic wall are degraded by excess MMPs. Acute and chronic cardiovascular diseases both exhibit dysregulation of the balance between MMPs and TIMPs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73226 | MMP-2 Inhibitor II | 869577-51-5 | MMP-2 Inhibitor II (Compound 2) is a selective inhibitor. |
|
V73239 | MMP-7-IN-1 | 2865097-05-6 | MMP-7-IN-1 is a potent and specific inhibitor of MMP-7 (IC50=10 nM), with IC50> for MMP-1, -2, -3, -8, -9, -13 11mM. |
|
V73229 | MMP-7-IN-2 | 2848717-49-5 | MMP-7-IN-2 (comp 16) is a selective inhibitor of MMP7 with IC50 of 16 nM. |
|
V73242 | MMP-7-IN-3 | 2865097-58-9 | MMP-7-IN-3 is a potent selective inhibitor of MMP-7. |
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V73235 | MMP-8 inhibitor-1 (MMP8-I) | 236403-25-1 | MMP-8 inhibitor-1 (compound 21) is a hydroxamic acid analogue that is a potent MMP-8 inhibitor (antagonist) without significant oral bioavailability (F). |
|
V73248 | MMP-8/MMP-26 Fluorogenic substrate | 135662-05-4 | MMP-8/MMP-26 Fluorogenic substrate (DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg) is a fluorescent substrate for matrix metalloproteinase 8 (MMP-8). |
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V73249 | MMP-9-IN-6 | 2241964-36-1 | MMP-9-IN-6 (Compound 3g) is an MMP-9 inhibitor (antagonist) with IC50 of 50 μM and good anti-ulcer efficacy. |
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V73236 | MMP-9-IN-7 | 333746-76-2 | MMP-9-IN-7 is a potent MMP9 inhibitor (antagonist) with IC50 of 0.52 μM in proMMP9/MMP3 P126 activation assay. |
|
V73221 | MMP-9/MMP-13 Inhibitor I | 204140-01-2 | MMP-9/MMP-13 Inhibitor I is a potent inhibitor of MMP-9 and MMP-13 with IC50 of 0.9 nM. |
|
V73227 | MMP13-IN-2 | 935759-55-0 | MMP13-IN-2 is a specific and orally bioactive MMP-13 inhibitor. |
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V73260 | MMP13-IN-4 | 514855-02-8 | MMP13-IN-4 (compound 13) is a potent and specific MMP-13 (IC50=14.6 μM) inhibitor that may be utilized to study osteoarthritis pain. |
|
V79484 | MMP13-IN-5 | MMP13-IN-5 (compound 13m) is a potent inhibitor of MMP-2/MMP-13 (IC50=3.6 μM/14.6 μM) and may be utilized to study osteoarthritis pain. | |
|
V73220 | MMPI-1154 | 1382722-47-5 | MMPI-1154 is a promising new cardiomyocyte-protective imidazole-carboxylate MMP-2 inhibitor (IC50=6.6 μM) that may be utilized in the study of acute myocardial infarction. |
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V31191 | Morroniside | 25406-64-8 | Morroniside exerts neuro-protective (neuro-protection) effects by inhibiting neuronal apoptosis and MMP9/2 expression. |
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V73234 | NFF-3 | 158584-09-9 | NFF-3 peptide is a selective MMP substrate. |
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V76706 | NFF-3 TFA | NFF-3 TFA peptide is a selective MMP substrate. | |
|
V73243 | o-Phenanthroline-d8 (1,10-Phenanthroline-d8) | 90412-47-8 | o-Phenanthroline-d8 is the deuterated form of o-Phenanthroline. |
|
V73246 | PF-00356231 | 766536-21-4 | PF-00356231 HCl is a non-peptide, non-zinc-chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). |
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V1913 | Phosphoramidon disodium salt | 164204-38-0 | Phosphoramidon disodium salt is a potent metalloendopeptidase inhibitor, which is widely used as a biochemical research tool. |
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V79591 | proMMP-9 selective inhibitor-1 | proMMP-9 selective inhibitor-1 is a highly efficient and selective inhibitor of proMMP-9 activation. |
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