Glutathione peroxidases (GPx) are a family of enzymes with the ability to reduce organic and inorganic hydroperoxides to the corresponding alcohols using glutathione or thioredoxin as an electron donor. These enzymes aid in the metabolism of hydrogen peroxide and guard against oxidative damage to the structure and operation of cell membranes. Severe pathologies like diabetes and obesity are associated with dysregulated GPx expression. In various tumor models, GPx1 has been implicated in both pro- and anticancer effects.
Eight members of the GPxs family have been identified in mammals (GPx1–GPx8); five of them (GPx1–GPx4 and GPx6) have selenocysteine in their catalytic centers, while the other three are cysteine-containing proteins. One of the GPxs family members that is most important for catalytically reducing hydrogen peroxide to produce water is GPx1. The job of GPx3 is to scavenge H2O2 and lipoperoxides in the plasma to lessen chronic oxidative stress and to keep vascular nitric oxide bioavailable. Gpx4 is a crucial mammalian glutathione peroxidase that controls ferroptosis, a novel type of controlled necrotic cell death. It also safeguards cells against harmful lipid peroxidation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73825 | MPO-IN-3 | 1435469-45-6 | MPO-IN-3 is a potent myeloperoxidase inhibitor (WO2013068875A1, example 191). |
|
V73826 | N-Acetyl lysyltyrosylcysteine amide | 1287585-40-3 | N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific and nontoxic tripeptide inhibitor of myeloperoxidase (MPO). |
|
V73778 | N-Caffeoyl O-methyltyramine | 189307-47-9 | N-Caffeoyl O-methyltyramine is a type of alkaloid extracted from Cuscuta reflexa. |
|
V73775 | Naringinase | 9068-31-9 | Naringinase is a hydrolase complex with α-L-rhamnosidase and β-D-glucosidase activities. |
|
V73783 | p-Hydroxyphenethyl trans-ferulate | 84873-15-4 | p-Hydroxyphenethyl trans-ferulate has anti-hyperglycemic (yeast alpha-glucosidase, IC50 19.24 ± 1.73 µmol L-1), antioxidant, and anti-inflammatory activities. |
|
V4475 | PF-06282999 | 1435467-37-0 | PF-06282999 is a novel, potent and selectivemyeloperoxidase(MPO)inhibitor with the potential for the treatment of cardiovascular diseases. |
|
V4426 | PF-1355 | 1435467-38-1 | PF-1355 (also known as PF-06281355), a 2-thiouracil analog, is a novel, potent,selective and orally bioavailable mechanism-based MPO inhibitor used for treatment of vasculitic diseases. |
|
V73787 | Prunetin 5-O-β-D-glucopyranoside | 89595-66-4 | Prunetin 5-O-β-D-glucopyranoside is an isoflavone extracted from Potentilla astracanica extract. |
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V73829 | Sorbifolin | 23130-22-5 | Sorbifolin is a flavonoid glycoside that can be extracted from Pterogyne nitens. |
|
V3104 | Tinoridine HCl (Y-3642 HCl) | 25913-34-2 | Tinoridine HCl (also known as Y-3642 HCl), the hydrochloride of tinoridine (Y-3642), is a nonsteroidal anti-inflammatory drug (NSAID) that also has potent radical scavenger and antiperoxidative activity. |
|
V73794 | Valienamine | 38231-86-6 | Valienamine is an alpha-glucosidase inhibitor. |
|
V73162 | Zampilimab (UCB-7858) | 2098280-42-1 | Zampilimab (UCB-7858) is a transglutaminase 2 (TG2) monoclonal antibody (mAb). |
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V73772 | α-Glucosidase (α-glucosidase; α-D-Glucosidase) | 9001-42-7 | α-Glucosidase (α-D-Glucosidase) is a carbohydrate hydrolase that catalyzes the release of α-glucose from the non-reducing end of the substrate. |
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V73785 | α-Glucosidase-IN-12 | 2816072-24-7 | α-Glucosidase-IN-12 (compound 14) is a potent α-glucosidase inhibitor (antagonist) with IC50 of 10.20 μM. |
|
V73792 | α-Glucosidase-IN-13 | 2816072-18-9 | α-Glucosidase-IN-13 (Compound 8) is an α-glucosidase inhibitor (antagonist) with IC50 of 5.69 μM. |
|
V73809 | α-Glucosidase-IN-14 | 2816072-15-6 | α-Glucosidase-IN-14 (compound 5) is a potent α-glucosidase inhibitor (antagonist) with IC50 of 5.22 μM. |
|
V73817 | α-Glucosidase-IN-15 | 2820424-85-7 | α-Glucosidase-IN-15 (Compound 14B) is a potent, orally bioactive α-glucosidase inhibitor (antagonist) with IC50 of 3.34 μM. |
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V73791 | α-Glucosidase-IN-17 | 2820424-84-6 | α-Glucosidase-IN-17 (Compound 12B) is a potent, orally bioactive α-glucosidase inhibitor (antagonist) with IC50 of 3.79 μM. |
|
V73801 | α-Glucosidase-IN-18 | 2820424-81-3 | α-Glucosidase-IN-18 (7B) is an orally bioactive α-glucosidase inhibitor (antagonist) with IC50 of 3.96 μM. |
|
V73803 | α-Glucosidase-IN-23 | 161187-57-1 | α-Glucosidase-IN-23 is an α-Glucosidase inhibitor (antagonist) with oral activity. |
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