Glutathione peroxidases (GPx) are a family of enzymes with the ability to reduce organic and inorganic hydroperoxides to the corresponding alcohols using glutathione or thioredoxin as an electron donor. These enzymes aid in the metabolism of hydrogen peroxide and guard against oxidative damage to the structure and operation of cell membranes. Severe pathologies like diabetes and obesity are associated with dysregulated GPx expression. In various tumor models, GPx1 has been implicated in both pro- and anticancer effects.
Eight members of the GPxs family have been identified in mammals (GPx1–GPx8); five of them (GPx1–GPx4 and GPx6) have selenocysteine in their catalytic centers, while the other three are cysteine-containing proteins. One of the GPxs family members that is most important for catalytically reducing hydrogen peroxide to produce water is GPx1. The job of GPx3 is to scavenge H2O2 and lipoperoxides in the plasma to lessen chronic oxidative stress and to keep vascular nitric oxide bioavailable. Gpx4 is a crucial mammalian glutathione peroxidase that controls ferroptosis, a novel type of controlled necrotic cell death. It also safeguards cells against harmful lipid peroxidation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73812 | α-Glucosidase-IN-24 | 60354-05-4 | α-Glucosidase-IN-24 (Compound 13) is an α-Glucosidase inhibitor (antagonist) with IC50 of 451 μM and can be extracted from Swertia kooutchensis. |
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V73811 | α-Glucosidase-IN-28 | 2949513-10-2 | α-Glucosidase-IN-28 (Compound 18) is an α-Glucosidase inhibitor (IC50= 0.62 μM, Ki: 3.93μM). |
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V73810 | α-Glucosidase-IN-29 | 2949513-11-3 | α-Glucosidase-IN-29 (compound 19) is an α-glucosidase inhibitor (IC50=1.21 μM, Ki=1.80 μM). |
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V73820 | α-Glucosidase-IN-35 | 24672-84-2 | α-Glucosidase-IN-35 is a chromene. |
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V73776 | β-Glucosidase | 9001-22-3 | β-Glucosidase is the rate-limiting enzyme for cellulose degradation. |
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V73781 | β-Hydroxypropiovanillone | 2196-18-1 | β-Hydroxypropiovanillone is a natural compound that has a significant concentration-dependent inhibitory activity against α-glucosidase (IC50=257.8 μg/mL). |
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