Glutathione peroxidases (GPx) are a family of enzymes with the ability to reduce organic and inorganic hydroperoxides to the corresponding alcohols using glutathione or thioredoxin as an electron donor. These enzymes aid in the metabolism of hydrogen peroxide and guard against oxidative damage to the structure and operation of cell membranes. Severe pathologies like diabetes and obesity are associated with dysregulated GPx expression. In various tumor models, GPx1 has been implicated in both pro- and anticancer effects.
Eight members of the GPxs family have been identified in mammals (GPx1–GPx8); five of them (GPx1–GPx4 and GPx6) have selenocysteine in their catalytic centers, while the other three are cysteine-containing proteins. One of the GPxs family members that is most important for catalytically reducing hydrogen peroxide to produce water is GPx1. The job of GPx3 is to scavenge H2O2 and lipoperoxides in the plasma to lessen chronic oxidative stress and to keep vascular nitric oxide bioavailable. Gpx4 is a crucial mammalian glutathione peroxidase that controls ferroptosis, a novel type of controlled necrotic cell death. It also safeguards cells against harmful lipid peroxidation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73816 | EB-0156 | 2832824-43-6 | EB-0156 is a potent inhibitor of ER α-glucosidase (α-Glu) I and II, with IC50s values of 0.0479 and less than 0.001 μM, respectively. |
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V73784 | EB-0176 | 2758314-64-4 | EB-0176 is a potent inhibitor of ER α-glucosidase (α-Glu) I and II, with IC50s values of 0.6439 and 0.0011 μM, respectively. |
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V73806 | Flaccidoside III | 140400-67-5 | Flaccidoside III is a flavonoid and triterpenoid extracted from the aerial parts of N.sativa (Ranunculaceae). |
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V73773 | Fucoidan (fucoidan; fucoidan) | 9072-19-9 | Fucoidan is a bioactive polysaccharide that is a potent inhibitor of alpha-amylase and alpha-glucosidase. |
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V73788 | Ganoderlactone D | 1801934-15-5 | Ganoderlactone D has inhibitory activity against α-glucosidase in yeast with IC50 of 41.7 μM. |
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V73819 | GCase modulator-1 | 796079-91-9 | GCase modulator-1 (compound 9g), an analogue of Quinazoline, is a modulator of GCase (Glucosidase) (AC50=2.23 μM). |
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V73805 | Glucocerebrosidease-IN-1 hydrochloride | 2279945-77-4 | Glucocerebrosidase-IN-1 (compound 11a) HCl is a potent and specific GCase inhibitor (antagonist) with IC50 of 29.3 μM and a Ki of 18.5 μM. |
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V73160 | Glutaminase-IN-3 | 1439399-45-7 | Glutaminase-IN-3 (compound 657) is a potent glutaminase inhibitor (antagonist) with IC50 of 0.24 μM for GLS1. |
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V73822 | Glutathione Peroxidase (GSH-Px; EC 1.11.1.9) | 9013-66-5 | Glutathione Peroxidase (GSH-Px; EC 1.11.1.9), glutathione peroxidase, belongs to the peroxidase family and is widely used in biochemical research. |
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V73828 | GPX4-IN-2 | 2485005-22-7 | GPX4-IN-2 is a potent GPX4 inhibitor. |
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V73827 | GPX4-IN-4 | 2920221-53-8 | GPX4-IN-4 (Compound 24) is a potent GPX4 inhibitor. |
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V73824 | JKE-1716 | 2421118-05-8 | JKE-1716 is a potent and specific nitrate-containing GPX4 inhibitor. |
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V73780 | Kaempferol-7-O-rhamnoside | 20196-89-8 | Kaempferol-7-O-rhamnoside is extracted from the leaves of Chimonanthus nitens Oliv and is a potent inhibitor of α-glucosidase activity. |
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V73797 | Kouitchenside G | 1444411-75-9 | Koutchenside G is a naturally occurring compound extracted from Swertia kooutchensis. |
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V73798 | L-Afegostat (5-epi-Isofagomine) | 202979-51-9 | L-Afegostat (5-epi-Isofagomine) is a glycosidase inhibitor. |
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V73815 | Lucidal (Lucialdehyde C) | 252351-96-5 | Lucidal (Lucialdehyde C) is a natural triterpene aldehyde compound that can inhibit α-glucosidase (Glucosidase) with IC50 of 0.635 mM. |
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V73823 | Mitiperstat (AZD4831) | 1933460-19-5 | Mitiperstat (AZD4831) is a potent inhibitor of myeloperoxidase (MPO). |
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V73821 | ML162-yne | 2883115-46-4 | ML162-yne is a potent GPX4 inhibitor affinity probe. |
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V73830 | MPO-IN-1 | 2471981-21-0 | MPO-IN-1 is a potent, orally bioactive, irreversible indole-containing myeloperoxidase (MPO) inhibitor (antagonist) with IC50s of 2.6 for MPO and thyroid peroxide (TPO) respectively. |
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V30689 | MPO-IN-28 | 37836-90-1 | MPO-IN-28 (Compound 28) is a myeloperoxidase (MPO) inhibitor (antagonist) with IC50 of 44 nM. |
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