An important part of apoptosis (programmed cell death), necrosis, and inflammation is played by the cysteine protease family known as caspase. Apoptotic caspases come in two varieties: effector (executioner) caspases and initiator (apical) caspases. Effector caspases are activated when initiator caspases, such as CASP2, CASP8, CASP9, and CASP10, cleave their inactive pro-forms. In order to start the apoptotic process, effector caspases (such as CASP3, CASP6, and CASP7) cleave other protein substrates inside the cell. Caspase inhibitors control how this cascade reaction gets started. Because they are inflammatory enzymes that cooperate with CASP1 to play a role in T-cell maturation, CASP4 and CASP5, which are overexpressed in some cases of vitiligo and related autoimmune diseases brought on by NALP1 variants, are not currently classified as initiators or effectors in MeSH.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V60112 | Dehydrocorydaline | 30045-16-0 | Dehydrocorydalin is an alkaloidal component isolated from Rhizoma corydalis. |
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V4486 | Emricasan | 254750-02-2 | Emricasan (formerly also known as IDN-6556 and PF 03491390) is a potent, first-in-class and irreversiblepan-caspaseinhibitor. |
|
V67696 | Estrogen receptor modulator 10 | 2991504-90-4 | Estrogen receptor modulator 10 (compound G-5b) is an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). |
|
V76051 | Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone | 1926163-65-6 | Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a cell-permeable (penetrable), non-toxic inhibitor that interacts with activated caspase in apoptotic cells -3 Irreversible binding. |
|
V0033 | Gambogic Acid (Guttatic Acid, Guttic Acid) | 2752-65-0 | Gambogic Acid (also called Guttatic Acid, Guttic Acid) is a naturally occurring xanthonoid isolated from the brownish or orange resin from Garcinia hanburyi. |
|
V5262 | Ginsenoside Rh2 | 78214-33-2 | Ginsenoside Rh2,a naturally occuring steroid glycoside andan aldose reductase inhibitor isolated from plants of the genusPanax,is isolated from the root ofGinsengwith diverse biological activities. |
|
V80350 | IETD-CHO TFA | IETD-CHO TFA (Caspase-8-IN-1) is a potent caspase-8 inhibitor. | |
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V75855 | KDM1/CDK1-IN-1 | 2938990-92-0 | KDM1/CDK1-IN-1 (compound 4) is a potent inhibitor of KDM1 and CDK1 with IC50s of 0.096 and 0.078 μM, respectively. |
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V23175 | KEA1-97 | 2138882-71-8 | KEA1-97 is a selective Thioredoxin-caspase 3 interaction interferer (IC50=10 μM). |
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V78417 | M826 | M826 is a specific and reversible non-peptide caspase-3 inhibitor (antagonist) with IC50 of 0.005 μM for caspase-3 enzymatic activity. | |
|
V4095 | MX-1013 | 582316-00-5 | MX1013 (Z-VD-fmk) is a novel, a potent and irreversible dipeptide pan-caspase inhibitor which inhibits caspases 1, 3, 6, 7, 8, and 9 with IC50 values ranging from 5 to 20 nm. |
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V4640 | NVP-231 | 362003-83-6 | NVP-231 is a novel, potent, specific, and reversible CerK inhibitor that competitively inhibits binding of ceramide to CerK with IC50 of 12±2 nM. |
|
V0025 | PAC-1 (VO-100) | 315183-21-2 | First procaspase-activating compound (PAC-1; VO 100) is a potent small-molecule activator of procaspase-3 that directly catalyzes the maturation of procaspase-3 to the active caspase-3 by inducing the cleavage of procaspase-3 in a time-dependent manner. |
|
V28830 | Penicillic acid | 90-65-3 | Penicillic acid is a novel and potent polyketide mycotoxinisolated from several species of Aspergillus and Penicillium with antibiotic and carcinogenic activity. |
|
V0031 | Q-VD-OPh | 1135695-98-5 | Q-VD-OPh (also known asQVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone) is a novel, potent and irreversiblepan-caspase inhibitor with potential anticancer activities. |
|
V30147 | Salinomycin sodium (Procoxacin) | 55721-31-8 | Salinomycinsodium(also known as Procoxacin, AHR-3096) is a potent antibacterial and coccidiostat ionophore therapeutic agent with potential anticancer activities by targeting stem cells. |
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V51574 | Sanggenon G | 85698-31-3 | XIAP inhibitor |
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V81358 | Sarglaroids F | Sarglaroids F (compound 6) is an anti-inflammatory agent extracted from the roots of Grass Coral. | |
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V81402 | Smac-N7, Penetratin conjugated | Smac-N7, Penetratin conjugated, is a caspase activator developed from the second mitochondria-derived caspase activator (SMAC). | |
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V0027 | Tasisulam (LY573636) | 519055-62-0 | Tasisulam(LY-573636), anacyl-sulfonamide analog,is a potent anticancer/tumor agent that is able toinduce tumor cell apoptosis by a mitochondrial-targeted mechanism involving the loss of mitochondrial membrane potential and induction of reactive oxygen species (ROS). |
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