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    InvivoChem Cat #: V0031
    CAS #: 1135695-98-5Purity ≥98%

    Description: Q-VD-OPh (also known as QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone) is a novel, potent and irreversible pan-caspase inhibitor with potential anticancer activities. It has IC50 values ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, and shows inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis. Q-VD-OPh was equally effective at inhibiting the three major apoptotic pathways, was functional in different cell types and species (human, mouse, and rat) and prevented terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis. The effectiveness of Q-VD-OPh as an apoptotic inhibitor is evidenced by the complete suppression of an apoptotic inducer capable of inducing substantial cell death in less than 4 hours.

    References:  Apoptosis. 2003 Aug;8(4):345-52; Chen-Deutsch X, et al. Leuk Res. 2012 Jul;36(7):884-8. The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells.

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    Molecular Weight (MW)513.49
    CAS No.1135695-98-5
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (194.74 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol: 100 mg/mL (194.74 mM)
    SynonymsQVD-OPH; Q-VD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone. quinoline-val-asp(OMe)-CH2-OPH.           
    Other info

    Chemical Name: (3S)-5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-2-(quinoline-2-carbonylamino)butanoyl]amino]-4-oxopentanoic acid


    InChi Code: InChI=1S/C26H25F2N3O6/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34)/t20-,23-/m0/s1

    SMILES Code: O=C(O)C[[email protected]](NC([[email protected]@H](NC(C1=NC2=CC=CC=C2C=C1)=O)C(C)C)=O)C(COC3=C(F)C=CC=C3F)=O

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    In VitroQ-VD-OPh (5-100 μM) potently inhibits Actinomycin D-induced DNA laddering and subsequent apoptosis with minimal toxicity in WEHI 231 cells. Q-VD-OPh prevents caspase mediated cleavage of PARP and activation of the major initiator and effector caspases. Q-VD-OPh protects cardiac myocytes from virus-induced apoptosis in vitro
    In VivoQ-VD-OPh inhibited caspase-7 activation and limited the pathological changes of tau and caspase cleavage in chronic treatment of Alzheimer disease.
    Animal modelTgCRND8 mice in 3 months-old
    Formulation & DosageIntraperitoneally Injected with 10 mg/kg QVD-OPh at 3 times a week for 3 months
    ReferencesJ Cell Biochem. 2011 Nov;112(11):3334-42; Int J Clin Exp Med. 2009 Nov 5;2(4):300-8.

    These protocols are for reference only. InvivoChem does not independently validate these methods.









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