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    Tasisulam
    Tasisulam

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0027
    CAS #: 519055-62-0Purity ≥98%

    Description: Tasisulam is an antitumor agent that induced growth arrest and apoptosis of human solid tumours. In human malignant hematopoietic cell lines, tasisulam inhibited cells growth with ED50 values of 5, 7, 12, 13, 21 and 31 μM for BALL1, HL60, RCH, NCEB1, SP49 and Daudi cell lines, respectively. Tasisulam induced growth arrest in a dose-dependent way. Also, tasisulam caused induction of ROS, loss of mitochondrial membrane potential and induction of apoptosis. In HL60 and U937 cells, tasisulam induce granulocytic/monocytic differentiation. 

    References: Oncol Rep. 2008 Nov;20(5):1237-42.


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    Molecular Weight (MW)415.11
    FormulaC11H6BrCl2NO3S2
    CAS No.519055-62-0
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 83 mg/mL (199.94 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol:
    Solubility (In vivo)


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    GeneralIn mice bearing the Calu-6 non-small cell lung xenograft model, tasisulam exhibited antitumor efficacy in a dose-dependent way and reduced tumor volume by 77%. Tasisulam caused G2-M accumulation and increased nuclear fragmentation. Also, tasisulam induced vascular normalization.
    Animal model Calu-6 non–small cell lung xenograft model
    Formulation saline
    Dosages 50 mg/kg
    Administration i.v.
    References[1] Meier T, et al. Mol Cancer Ther. 2011, 10(11), 2168-2178.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     

    Tasisulam

    In vitro effects of tasisulam on endothelial and adipose-derived stem cells. Mol Cancer Ther. 2011 Nov;10(11):2168-78.
     
    Tasisulam
    Effects of tasisulam on blood vessel formation in vivo. Mol Cancer Ther. 2011 Nov;10(11):2168-78.
     

    Tasisulam

    Tasisulam displays dose-dependent antitumor activity, induces apoptosis, and normalizes tumor-associated vasculature in the Calu-6 non–small cell lung xenograft model. Mol Cancer Ther. 2011 Nov;10(11):2168-78.


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