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    Tasisulam (LY573636)
    Tasisulam (LY573636)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0027
    CAS #: 519055-62-0Purity ≥98%

    Description: Tasisulam (LY-573636), an acyl-sulfonamide analog, is a potent anticancer/tumor agent that is able to  induce tumor cell apoptosis by a mitochondrial-targeted mechanism involving the loss of mitochondrial membrane potential and induction of reactive oxygen species (ROS). It acts as an apoptosis inducer and caspase activator.

    References: Oncol Rep. 2008 Nov;20(5):1237-42.

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    Molecular Weight (MW)415.11
    CAS No.519055-62-0
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 83 mg/mL (199.94 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol: N/A
    SynonymsLY573636, LY 573636, LY-573636, Tasisulam, Tasisulam sodium

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    GeneralIn mice bearing the Calu-6 non-small cell lung xenograft model, tasisulam exhibited antitumor efficacy in a dose-dependent way and reduced tumor volume by 77%. Tasisulam caused G2-M accumulation and increased nuclear fragmentation. Also, tasisulam induced vascular normalization.
    Animal model Calu-6 non–small cell lung xenograft model
    Formulation saline
    Dosages 50 mg/kg
    Administration i.v.
    References[1] Meier T, et al. Mol Cancer Ther. 2011, 10(11), 2168-2178.

    These protocols are for reference only. InvivoChem does not independently validate these methods.



    In vitro effects of tasisulam on endothelial and adipose-derived stem cells. Mol Cancer Ther. 2011 Nov;10(11):2168-78.
    Effects of tasisulam on blood vessel formation in vivo. Mol Cancer Ther. 2011 Nov;10(11):2168-78.


    Tasisulam displays dose-dependent antitumor activity, induces apoptosis, and normalizes tumor-associated vasculature in the Calu-6 non–small cell lung xenograft model. Mol Cancer Ther. 2011 Nov;10(11):2168-78.


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