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    PAC-1
    PAC-1

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0025
    CAS #: 315183-21-2Purity ≥98%

    Description: First procaspase-activating compound (PAC-1) is a small-molecule activator of procaspase-3 that directly catalyzes the maturation of procaspase-3 to the active caspase-3 by inducing the cleavage of procaspase-3 in a time-dependent manner. Study results have demonstrated that PAC-1 is able to induce cell death in both primary cancerous cells and adjacent normal tissues with 50% inhibition concentration IC50 values ranging from 0.003 to 1.41 μM and 5.02 to 9.98 μM respectively.

    References: Nat Chem Biol. 2006 Oct;2(10):543-50.


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    Molecular Weight (MW)392.49
    FormulaC23H28N4O2
    CAS No.315183-21-2
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 78 mg/mL (198.73 mM)
    Water:<1 mg/mL (slightly soluble or insoluble)
    Ethanol: 16 mg/mL (40.76 mM)
    Solubility (In vivo) 30% PEG400+0.5% Tween80+5% Propylene glycol: 30mg/mL


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    GeneralAdministration of PAC-1 at 5 mg with low and steady releasing significantly inhibits the growth of ACHN renal cancer xenograft in mice. Oral administration of PAC-1 (50 or 100 mg/kg) significantly retards tumor growth of NCI-H226 lung cancer xenograft in a dose-dependent manner, and markedly prevents the cancer cells from infiltrating the lung tissue.
    Animal modelMice s.c. injected with NCI-H226 (lung cancer) cells
    FormulationMixed with cholesterol and pelleted into a 3-mm-diameter 20-mg (total weight) pellet, or dissolved in a mixture of 24:1 vegetable oil/DMSO
    Dosages0, 50 or 100 mg/kg;
    Administrationp.o.; q.d., for 21 days
    References[1] Putt KS, et al. Nat Chem Biol, 2006, 2(10), 543-550.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     

    PAC-1

     

    PAC-1



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