The acquired immunodeficiency syndrome (AIDS), a condition in which the immune system gradually fails and life-threatening opportunistic infections and cancers proliferate, is brought on by the lentivirus (a subgroup of retrovirus) known as HIV. HIV infection happens when blood, semen, vaginal fluid, pre-ejaculate, or breast milk are shared. HIV can be found in these bodily fluids as both free virus particles and as a virus inside infected immune cells.Important immune system components like helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells are all infected by HIV. Apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells are some of the mechanisms by which HIV infection results in low levels of CD4+ T cells. Cell-mediated immunity is lost and the body becomes progressively more vulnerable to opportunistic infections when CD4+ T cell counts fall below a critical threshold.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V54280 | Bavtavirine | 1956373-71-9 | Bavtavirine is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) that is part of the highly active antiretroviral therapy (HAART) regimen. |
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V3601 | Bevirimat | 174022-42-5 | Bevirimat (formerly known as PA-457, MPC-4326 and YK FH312), an analog of betulinic acid, is a novel and potent anti-HIV drug that acts as a maturation inhibitor. |
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V52342 | BI-2540 | 875145-22-5 | BI-2540 is an HIV non-nucleoside reverse transcriptase (NNRT) inhibitor. |
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V3902 | BICTEGRAVIR | 1611493-60-7 | Bictegravir (formerly BIC; GS-9883; trade name:Biktarvyfor the combination of bictegravir, embitcitabine, tenofovir alafenamide) is a novel, potent, once-daily, unboosted inhibitor of HIV-1 integrase (IN) approved in 2018 for HIV treatment. |
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V1839 | BMS-378806 | 357263-13-9 | BMS-378806 (also known as BMS 806)is a novel, potent, orally bioavailable small molecule thatselectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in HIV virus. |
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V54293 | BNM-III-170 | 1859189-55-1 | BNM-III-170 can inhibit HIV-1 from entering target cells. |
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V52992 | Bz-RS-iSer(3-Ph)-OMe | 32981-85-4 | Bz-RS-iSer(3-Ph)-OMe (compound 2) is a paclitaxel analogue that can inhibit the HSV replication cycle with low cytotoxic effect, blocks mitosis of Vero cells, affects M-MSV-induced tumor size, and inhibits PHA induces T lymphocyte proliferation and affects immune response. |
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V78593 | C34 peptide | C34 peptide is a biologically active peptide. | |
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V54303 | Calceolarioside A | 84744-28-5 | Calceolarioside A is a phenylethanoid glycoside with moderate binding affinity for HIV gp41. |
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V76071 | Calcium mesoxalate (Ketomalonic acid calcium; Mesoxalic acid calcium; Oxomalonic acid calcium) | 21085-60-9 | Calcium mesoxalate blocks HIV-1 reverse transcriptase (HIV-1 RT) with IC50 of 2.2 μM. |
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V54288 | Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl | 129988-00-7 | Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl (Compound (CPF(LL))) is an HIV-1 inhibitor. |
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V54290 | Carbovir triphosphate (CBV-TP; (-)-Carbovir triphosphate; (-)-Carbovir 5′-triphosphate) | 129941-14-6 | Carbovir triphosphate (CBV-TP) is a phosphorylated metabolite. |
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V34813 | Claficapavir (A1752) | 2055732-24-4 | Claficapavir (A1752) is a specific nucleocapsid protein inhibitor (antagonist) with IC50 of approximately 1μM. |
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V76168 | Clathrin-IN-1 | 1332879-52-3 | Clathrin-IN-1 is a selective clathrin-mediated endocytosis (CME) inhibitor. |
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V79847 | Clavirolide L | Clavirolide L (Compound 3) is a dolabane diterpenoid extracted from Clavularia viridis. | |
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V78974 | Cys(Npys)-TAT (47-57) | Cys(Npys)-TAT (47-57) is a bioactive peptide segment of the TAT polypeptide that can form electrostatic interactions with plasmid DNA. | |
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V77112 | Cys-TAT(47-57) TFA (Cys-[HIV-Tat (47-57)] TFA) | Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) is a cell-penetrable arginine-rich dodecapeptide and an analogue of HIV-1 transactivator protein. | |
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V51565 | Dapivirine-d11 (TMC-120-d11; R-147681-d11) | 1329613-10-6 | deuterium labeled Dapivirine |
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V51078 | Darunavir-d9 (TMC-114-d9; UIC-94017-d9) | 1133378-37-6 | deuterium labeled form of Darunavir-d9 |
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V54271 | Daurichromenic acid ((+)-Daurichromenic acid) | 82003-90-5 | Daurichromenic acid is a pigment that can be extracted from the leaves and branches of Rhododendron dauricum. |
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