The acquired immunodeficiency syndrome (AIDS), a condition in which the immune system gradually fails and life-threatening opportunistic infections and cancers proliferate, is brought on by the lentivirus (a subgroup of retrovirus) known as HIV. HIV infection happens when blood, semen, vaginal fluid, pre-ejaculate, or breast milk are shared. HIV can be found in these bodily fluids as both free virus particles and as a virus inside infected immune cells.Important immune system components like helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells are all infected by HIV. Apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells are some of the mechanisms by which HIV infection results in low levels of CD4+ T cells. Cell-mediated immunity is lost and the body becomes progressively more vulnerable to opportunistic infections when CD4+ T cell counts fall below a critical threshold.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V52193 | DDX3-IN-2 | 1919828-81-1 | DDX3-IN-2 is an active DEADbox polypeptide 3 (DDX3) inhibitor (antagonist) with IC50 of 0.3 μM. |
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V54294 | Deaminase inhibitor-1 | 397878-17-0 | Deaminase inhibitor-1 is a small molecule inhibitor of APOBEC3G DNA deaminase, with IC50 of 18.9 μM. |
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V52191 | Decanoyl-RVKR-CMK TFA (DecRVKRcmk TFA) | 2098497-25-5 | Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits overexpression of gp160 processing and HIV-1 replication. |
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V73990 | DGKα-IN-8 | 2886717-70-8 | DGKα-IN-8 (Example 51) is a DGKα inhibitor (IC50=22.491 nM; EC50=0.256 nM). |
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V53159 | Dimercaprol (dimercaptopropanol; 2,3-Dimercapto-1-propanol; Dithioglycerol) | 59-52-9 | Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal poisoning agent with anti-HIV (Human Immunodeficiency Virus) activity. |
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V35046 | Ditiocarb (Diethyldithiocarbamic acid) | 147-84-2 | Ditiocarb (Diethyldithiocarbamic acid) is a copper reagent that reacts with Cu2+ solution to form a complex, which increases the copper replacement precipitation rate. |
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V52728 | Ditiocarb-d10 sodium | 1261395-23-6 | Ditiocarb-d10 (sodium) is the deuterated form of Ditiocarb sodium. |
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V33193 | Dolutegravir intermediate-1 | 1335210-23-5 | Dolutegravir intermediate-1 is anintermediate to the synthesis of dolutegravirwhich is an HIV integrase inhibitor for the treatment of human immunodeficiency virus (HIV)-l infection. |
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V52164 | Dolutegravir sodium (Dolutegravir sodium; S/GSK1349572 sodium) | 1051375-19-9 | Dolutegravir sodium (S/GSK1349572 sodium) is a potent, oral HIV integrase strand transfer inhibitor (antagonist) with IC50 of 2.7 nM in HIV-1 integrase-catalyzed strand transfer. |
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V79194 | Dolutegravir-d3 (S/GSK1349572-d3) | Dolutegravir-d3 is the deuterium labelled form of Dolutegravir. | |
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V3874 | doravirine | 1338225-97-0 | Doravirine (formerlyknown as MK-1439 and DOR; trade name:Pifeltro) is a novel human immunodeficiency type 1 virus (HIV-1) nonnucleoside reverse transcriptase inhibitor (NNRTI) that is approved in August 2018 to treat HIV-1 infection in adult patients. |
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V54299 | Elipovimab | 2101210-43-7 | Elipovimab is a potent, broadly neutralizing HIV-1 antibody for targeted elimination of HIV-infected cells |
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V20470 | Elsulfavirine | 868046-19-9 | Elsulfavirine is a reverse transcriptase inhibitor for HIV-1 infection and a new active molecule against HIV. |
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V32666 | Emtricitabine S-oxide (Emtricitabine sulfoxide) | 152128-77-3 | Emtricitabine S-oxide (also called Emtricitabine Degradant-III; Emtricitabine sulfoxide) is a degradation product (S-oxidized impurity) of Emtricitabine(BW-1592; FTC; BW1592;Emtriva;Coviracil; Racivir), which is a potent nucleoside reverse transcriptase inhibitor (NRTI) that has been approved for the treatment of both human immunodeficiency virus (HIV) and hepatitis B virus. |
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V54272 | Emtricitabine triphosphate ((-)-Emtricitabine triphosphate) | 145819-92-7 | Emtricitabine triphosphate ((-)-Emtricitabine triphosphate) is the phosphorylated anabolite of emtricitabine . |
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V32544 | Enfuvirtide | 159519-65-0 | Enfuvirtide, apeptide-based anti-HIV-1 fusion inhibitor, isan approved antiviral medication that prevents human immunodeficiency virus (HIV) from infecting healthy cells in the body. |
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V34696 | Enfuvirtide acetate (enfuvirtide acetate; T20 acetate; DP178 acetate) | 914454-00-5 | Enfuvirtide (T20; DP178) acetate is an anti-HIV (Human Immunodeficiency Virus)-1 fusion inhibitory peptide. |
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V54300 | Epicoccone B | 1067224-41-2 | Epicoccone B was first reported in C.globosum. |
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V52101 | F1839-I | 159096-49-8 | F1839-I is a compound that can be extracted from Stachybotrys and has weak cytotoxic effect and anti-HIV activity with IC50 of 15.6 μM. |
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V53868 | Feglymycin | 209335-49-9 | Feglymycin is an HIV replication inhibitor. |
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