The acquired immunodeficiency syndrome (AIDS), a condition in which the immune system gradually fails and life-threatening opportunistic infections and cancers proliferate, is brought on by the lentivirus (a subgroup of retrovirus) known as HIV. HIV infection happens when blood, semen, vaginal fluid, pre-ejaculate, or breast milk are shared. HIV can be found in these bodily fluids as both free virus particles and as a virus inside infected immune cells.Important immune system components like helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells are all infected by HIV. Apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells are some of the mechanisms by which HIV infection results in low levels of CD4+ T cells. Cell-mediated immunity is lost and the body becomes progressively more vulnerable to opportunistic infections when CD4+ T cell counts fall below a critical threshold.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V54264 | Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium | 2611373-74-9 | Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) displays longer t1/2 values than tenofovir in human liver microsomes, has potent anti-HIV activity in vitro, and enhances pharmacokinetic properties in vivo. |
|
V54269 | Tenofovir-C3-O-C15-CF3 ammonium | 2611373-80-7 | Tenofovir-C3-O-C15-CF3 (ammonium) displays longer t1/2 values than tenofovir in human liver microsomes, has potent anti-HIV activity in vitro, and enhances pharmacokinetic properties in vivo. |
|
V54247 | Teropavimab (3BNC117-LS; GS-5423) | 2417213-72-8 | Teropavimab (3BNC117-LS) is an antibody. |
|
V54253 | Tifuvirtide (T-1249) | 251562-00-2 | Tifuvirtide (T-1249) is a bioactive peptide human immunodeficiency virus type 1 (HIV-1) fusion inhibitor. |
|
V35196 | Tigloylgomisin P (crotonylgomisin P) | 69176-51-8 | Tigloylgomisin P is a lignin with anti-HIV (Human Immunodeficiency Virus) activity with EC50 of 37 μM. |
|
V50921 | TN-14003 | 368874-31-1 | anti-HIV peptide |
|
V53221 | Trecovirsen (GEM91) | 153021-75-1 | Trecovirsen (GEM91) is an antisense oligonucleotide targeting the HIV gag gene. |
|
V52922 | Trovirdine (Travirdine; LY300046) | 149488-17-5 | Trovirdine inhibits HIV-1 reverse transcription with IC50 of 7 nM. |
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V54284 | Tsugafolin | 66568-97-6 | Tsugafolin (compound 4) is a dehydroflavone with weak anti-HIV activity (IC50=118 μM) and no cytotoxic effect (<150 μM). |
|
V81736 | VIR-165 | VIR-165 is a modified form of a viral inhibitory peptide (VIRIP) that binds to a fusion peptide of the gp41 subunit and prevents its entry into target membranes. | |
|
V54243 | Wilfortrine (triptolide) | 37239-48-8 | Wilfortrine is a bioactive sesquiterpene alkaloid. |
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V54267 | Zinlirvimab (10-1074) | 2417213-75-1 | Zinlirvimab is a humanized IgG1-λ2 HIV neutralizing antibody that targets the HIV-1 gp120 envelope glycoprotein (IIIB gp120 V3 loop). |
|
V76070 | β-Rubromycin | 27267-70-5 | β-Rubromycin is a potent and specific inhibitor of human immunodeficiency virus-1 (HIV-1) RNA-directed DNA polymerase (reverse transcriptase). |
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